PMID- 25345253
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20181202
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 97
IP  - 8
DP  - 2014 Aug
TI  - Comparative study of nerve fiber density between adenomyosis patients with 
      moderate to severe pain and mild pain.
PG  - 791-7
AB  - BACKGROUND: Since some retrospective studies have given inconsistent findings 
      about innervation in adenomyosis, its role in the pain mechanism is still 
      inconclusive. OBJECTIVE: Define the nerve fiber density in adenomyotic tissue as 
      it correlated to pain symptoms. MATERIAL AND METHOD: A cross-sectional study was 
      performed in twenty-five uterine samples from reproductive age women with 
      adenomyosis who underwent either laparotomy or laparoscopic surgery. The nerve 
      fiber density from hysterectomized specimens as measured by immunohistochemistry 
      staining for Protein gene product (PGP) 9.5 and Neurofilament (NF) were compared 
      with the level of pain in the patients as defined by a visual analogue scale and 
      a verbal rating scale. RESULTS: Nerve fibers as detected by PGP9.5 and NF 
      staining in the myometrium were significantly increased in the group of women 
      with adenomyosis experiencing moderate and severe pain as compared to the group 
      experiencing less pain (4 (0, 7) vs. 1.55 (0, 7)/mm2, p-value <0.001, and 6 (3, 
      10) vs. 0 (0, 4)/mm2, p-value <0.001 respectively). At both phases of the 
      menstrual cycle, the densities of nerve fibers stained with PGP9.5 and NF showed 
      no significant difference. CONCLUSION: These results suggested that the increased 
      of nerve fibers shown in the more severe pain group might play a role in the 
      pathogenesis or symptoms of adenomyosis.
FAU - Lertvikool, Srithean
AU  - Lertvikool S
FAU - Sukprasert, Matchuporn
AU  - Sukprasert M
FAU - Pansrikaew, Pokpong
AU  - Pansrikaew P
FAU - Rattanasiri, Sasivimol
AU  - Rattanasiri S
FAU - Weerakiet, Sawaek
AU  - Weerakiet S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Adenomyosis/*pathology/surgery
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laparoscopy/methods
MH  - Laparotomy/methods
MH  - Menstrual Cycle/physiology
MH  - Middle Aged
MH  - Myometrium/*innervation
MH  - Nerve Fibers/*metabolism
MH  - Pain/*etiology/physiopathology
MH  - Pain Measurement
MH  - Retrospective Studies
MH  - Severity of Illness Index
EDAT- 2014/10/28 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/10/28 06:00
PHST- 2014/10/28 06:00 [entrez]
PHST- 2014/10/28 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2014 Aug;97(8):791-7.