PMID- 25346123
OWN - NLM
STAT- MEDLINE
DCOM- 20150516
LR  - 20200113
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 43
IP  - 8
DP  - 2014 Aug
TI  - [Chromosomal translocation involving USP6 gene in nodular fasciitis].
PG  - 533-6
AB  - OBJECTIVE: To investigate the frequency of USP6 gene rearrangement in nodular 
      fasciitis (NF) and to evaluate its clinical application. METHODS: Twenty nine 
      cases of previously diagnosed NF were screened for the presence of the USP6 gene 
      rearrangement by interphase fluorescence-in-situ hybridization (FISH) on 
      formalin-fixed paraffin-embedded tissue. Fifteen of these cases, which had 
      available tissue, were also analysed for MYH9-USP6 fusion transcripts by reverse 
      transcription-polymerase chain reaction (RT-PCR). RESULTS: Twenty four of the 29 
      cases (83%) were positive for the USP6 gene rearrangement by interphase FISH. The 
      15 cases with RT-PCR showed the following results: 11 positive, one deletion and 
      three negative for USP6 gene rearrangement. Of these 15 cases, eight (8/15) 
      showed MYH9-USP6 fusion transcript by RT-PCR. Of these eight cases, seven were 
      positive for USP6 gene rearrangement and one showed USP6 deletion by FISH. 
      CONCLUSIONS: USP6 gene rearrangement is a recurrent genetic event in NF. It is a 
      valuable ancillary tool for the pathological diagnosis of these lesions.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Pathology, the Affiliated Tumor Hospital of Guangxi Medical 
      University, Nanning 530021, China.
FAU - Ye, Xinqing
AU  - Ye X
FAU - Li, Yao
AU  - Li Y
FAU - Wei, Changhong
AU  - Wei C
FAU - Zheng, Qian
AU  - Zheng Q
FAU - Zhong, Ping
AU  - Zhong P
FAU - Wu, Shengming
AU  - Wu S
FAU - Luo, Yuan
AU  - Luo Y
FAU - Liao, Zhiling
AU  - Liao Z
FAU - Ye, Hongtao
AU  - Ye H
AD  - E-mail: dr.hongtaoye@googlemail.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 3.4.19.12 (USP6 protein, human)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Fasciitis/*genetics
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Proto-Oncogene Proteins/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Translocation, Genetic
MH  - Ubiquitin Thiolesterase/*genetics
EDAT- 2014/10/28 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/10/28 06:00
PHST- 2014/10/28 06:00 [entrez]
PHST- 2014/10/28 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2014 Aug;43(8):533-6.