PMID- 25346888
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141027
LR  - 20231104
IS  - 2220-3230 (Print)
IS  - 2220-3230 (Electronic)
IS  - 2220-3230 (Linking)
VI  - 4
IP  - 3
DP  - 2014 Sep 24
TI  - Methodological aspects of anti-human leukocyte antigen antibody analysis in solid 
      organ transplantation.
PG  - 153-67
LID - 10.5500/wjt.v4.i3.153 [doi]
AB  - Donor human leukocyte antigen (HLA)-specific antibodies (DSA) play an important 
      role in solid organ transplantation. Preexisting IgG isotype DSA are considered a 
      risk factor for antibody mediated rejection, graft failure or graft loss. The 
      post-transplant development of DSA depends on multiple factors including 
      immunogenicity of mismatched antigens, HLA class II typing of the recipient, 
      cytokine gene polymorphisms, and cellular immunoregulatory mechanisms. De novo 
      developed antibodies require special attention because not all DSA have equal 
      clinical significance. Therefore, it is important for transplant clinicians and 
      transplant immunologists to accurately characterize DSA. In this review, the 
      contemporary immunological techniques for detection and characterization of 
      anti-HLA antibodies and their pitfalls are described.
FAU - Lobashevsky, Andrew L
AU  - Lobashevsky AL
AD  - Andrew L Lobashevsky, Histocompatibility Laboratory, Department of Medicine, 
      School of Medicine, Indiana University, Indianapolis, IN 46202, United States.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Transplant
JT  - World journal of transplantation
JID - 101608356
PMC - PMC4208078
OTO - NOTNLM
OT  - Antibodies
OT  - Flow cytometry
OT  - Human leukocyte antigen
OT  - Solid phase analysis
OT  - Transplantation
EDAT- 2014/10/28 06:00
MHDA- 2014/10/28 06:01
PMCR- 2014/09/24
CRDT- 2014/10/28 06:00
PHST- 2014/03/21 00:00 [received]
PHST- 2014/06/16 00:00 [revised]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/10/28 06:00 [entrez]
PHST- 2014/10/28 06:00 [pubmed]
PHST- 2014/10/28 06:01 [medline]
PHST- 2014/09/24 00:00 [pmc-release]
AID - 10.5500/wjt.v4.i3.153 [doi]
PST - ppublish
SO  - World J Transplant. 2014 Sep 24;4(3):153-67. doi: 10.5500/wjt.v4.i3.153.