PMID- 25347540
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20211021
IS  - 1939-1293 (Electronic)
IS  - 0893-3200 (Print)
IS  - 0893-3200 (Linking)
VI  - 28
IP  - 6
DP  - 2014 Dec
TI  - Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR 
      influence depressive symptoms.
PG  - 947-56
LID - 10.1037/fam0000032 [doi]
AB  - Functional genetic polymorphisms associated with Brain-Derived Neurotrophic 
      Factor (BDNF) and serotonin (5-HTTLPR) have demonstrated associations with 
      depression in interaction with environmental stressors. In light of evidence for 
      biological connections between BDNF and serotonin, it is prudent to consider 
      genetic epistasis between variants in these genes in the development of 
      depressive symptoms. The current study examined the effects of val66met, 
      5-HTTLPR, and family environment quality on youth depressive symptoms in 
      adolescence and young adulthood in a longitudinal sample oversampled for maternal 
      depression history. A differential susceptibility model was tested, comparing the 
      effects of family environment on depression scores across different levels of a 
      cumulative plasticity genotype, defined as presence of both, either, or neither 
      plasticity alleles (defined here as val66met Met and 5-HTTLPR 'S'). Cumulative 
      plasticity genotype interacted with family environment quality to predict 
      depression among males and females at age 15. After age 15, however, the 
      interaction of cumulative plasticity genotype and early family environment 
      quality was only predictive of depression among females. Results supported a 
      differential susceptibility model at age 15, such that plasticity allele presence 
      was associated with more or less depressive symptoms depending on valence of the 
      family environment, and a diathesis-stress model of gene-environment interaction 
      after age 15. These findings, although preliminary because of the small sample 
      size, support prior results indicating interactive effects of 5-HTTLPR, val66met, 
      and environmental stress, and suggest that family environment may have a stronger 
      influence on genetically susceptible women than men.
FAU - Dalton, Elizabeth D
AU  - Dalton ED
AD  - Department of Psychology, University of California, Los Angeles.
FAU - Hammen, Constance L
AU  - Hammen CL
AD  - Department of Psychology, University of California, Los Angeles.
FAU - Najman, Jake M
AU  - Najman JM
AD  - School of Population Health, University of Queensland.
FAU - Brennan, Patricia A
AU  - Brennan PA
AD  - Department of Psychology, Emory University.
LA  - eng
GR  - R01 MH052239/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141027
PL  - United States
TA  - J Fam Psychol
JT  - Journal of family psychology : JFP : journal of the Division of Family Psychology 
      of the American Psychological Association (Division 43)
JID - 8802265
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cohort Studies
MH  - Depressive Disorder/*genetics/*psychology
MH  - Epistasis, Genetic/genetics
MH  - Family Conflict/*psychology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Young Adult
PMC - PMC5510745
MID - NIHMS879813
EDAT- 2014/10/28 06:00
MHDA- 2016/04/06 06:00
PMCR- 2017/07/14
CRDT- 2014/10/28 06:00
PHST- 2014/10/28 06:00 [entrez]
PHST- 2014/10/28 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
PHST- 2017/07/14 00:00 [pmc-release]
AID - 2014-44480-001 [pii]
AID - 10.1037/fam0000032 [doi]
PST - ppublish
SO  - J Fam Psychol. 2014 Dec;28(6):947-56. doi: 10.1037/fam0000032. Epub 2014 Oct 27.