PMID- 25348726
OWN - NLM
STAT- MEDLINE
DCOM- 20161110
LR  - 20211021
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 31
IP  - 2
DP  - 2016 Feb
TI  - Effects of nocturnal oxygen therapy in patients with chronic heart failure and 
      central sleep apnea: CHF-HOT study.
PG  - 165-72
LID - 10.1007/s00380-014-0592-6 [doi]
AB  - It was previously reported that nocturnal home oxygen therapy (HOT) significantly 
      improved not only sleep disordered breathing (SDB), but also quality of life 
      (QOL) and left ventricular ejection fraction (LVEF) in two trials. To strengthen 
      the statistical reliability of the above efficacies of HOT and to assess the 
      effects of 12-week nocturnal HOT on suppression of ventricular arrhythmias, we 
      combined the two trials and undertook a post hoc analysis. Ninety-seven patients 
      with chronic heart failure (CHF) and central sleep apnea were assigned to receive 
      HOT (45 patients) or not (52 patients). HOT resulted in greater reduction in the 
      apnea-hypopnea index (AHI) (-11.4 +/- 11.0 vs. -0.2 +/- 7.6 events/h, p < 0.01), 
      which is associated with greater improvement in the Specific Activity Scale (0.8 
      +/- 1.2 vs. 0.0 +/- 0.6, p < 0.01), New York Heart Association (NYHA) functional 
      class (p < 0.01), and LVEF (p = 0.06). Median number of premature ventricular 
      contraction (PVC) at baseline was 17 beats per hour in both the HOT and the 
      control groups. Overall improvements of PVCs were not different either in the HOT 
      group or in the control. However, in 12 patients with NYHA >III and AHI >20 
      events/h, PVC was significantly improved by HOT with a marked reduction in AHI 
      and a substantial increase in LVEF. In conclusion, among patients with CHF and 
      CSA, HOT improves SDB, QOL, and cardiac function. The effectiveness of HOT for 
      ventricular arrhythmias was not observed in the overall analysis, but only in a 
      limited number of patients with severe CHF and SDB. To clarify the effects of HOT 
      on ventricular arrhythmias in patients with CHF and SDB, a further study is 
      needed.
FAU - Nakao, Yoko M
AU  - Nakao YM
AD  - Department of EBM Research, Institute for Advancement of Clinical and 
      Translational Science, Kyoto University Hospital, 54 Shogoinkawaharacho, 
      Sakyo-Ku, Kyoto, 606-8507, Japan.
FAU - Ueshima, Kenji
AU  - Ueshima K
AD  - Department of EBM Research, Institute for Advancement of Clinical and 
      Translational Science, Kyoto University Hospital, 54 Shogoinkawaharacho, 
      Sakyo-Ku, Kyoto, 606-8507, Japan. ueshima.kenji.5m@kyoto-u.ac.jp.
FAU - Yasuno, Shinji
AU  - Yasuno S
AD  - Department of EBM Research, Institute for Advancement of Clinical and 
      Translational Science, Kyoto University Hospital, 54 Shogoinkawaharacho, 
      Sakyo-Ku, Kyoto, 606-8507, Japan.
FAU - Sasayama, Shigetake
AU  - Sasayama S
AD  - Uji Hospital, Uji, Japan.
LA  - eng
PT  - Journal Article
DEP - 20141028
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/complications/diagnosis/*physiopathology
MH  - Heart Rate
MH  - *Home Care Services
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Inhalation Therapy/*methods
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Sleep Apnea, Central/complications/diagnosis/physiopathology/*therapy
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - Ventricular Premature Complexes/etiology/physiopathology
OTO - NOTNLM
OT  - Arrhythmia
OT  - Heart failure
OT  - Home oxygen therapy
OT  - Quality of life
OT  - Sleep apnea
EDAT- 2014/10/29 06:00
MHDA- 2016/11/12 06:00
CRDT- 2014/10/29 06:00
PHST- 2013/11/26 00:00 [received]
PHST- 2014/10/10 00:00 [accepted]
PHST- 2014/10/29 06:00 [entrez]
PHST- 2014/10/29 06:00 [pubmed]
PHST- 2016/11/12 06:00 [medline]
AID - 10.1007/s00380-014-0592-6 [pii]
AID - 10.1007/s00380-014-0592-6 [doi]
PST - ppublish
SO  - Heart Vessels. 2016 Feb;31(2):165-72. doi: 10.1007/s00380-014-0592-6. Epub 2014 
      Oct 28.