PMID- 25350112
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 11
DP  - 2014 Oct 27
TI  - Hyperhomocysteinemia accelerates collagen accumulation in the adventitia of 
      balloon-injured rat carotid arteries via angiotensin II type 1 receptor.
PG  - 19487-98
LID - 10.3390/ijms151119487 [doi]
AB  - Recent studies suggest that hyperhomocysteinemia (HHcy) increases collagen type I 
      accumulation in rat vascular adventitia after balloon injury and that Angiotensin 
      II (Ang II) induces collagen synthesis in vascular adventitial fibroblasts. 
      Reports also indicate that Ang II type1 receptor (AT1R) activation, mediated by 
      homocysteine (Hcy) may contribute to collagen type 1 expression in mouse aortic 
      endothelial cells. However, little is known about the possible mechanisms behind 
      the relationship between Hcy and AT1R in adventitial remodeling. Thus, we 
      investigated whether HHcy induces collagen accumulation via activation of AT1R in 
      the adventitia. Male Sprague-Dawley (SD) rats were randomly divided into a 
      control group and a 1% l-methionine-induced HHcy group. Balloon injury was 
      performed after 12 experimental weeks and animals were sacrificed at 7, 14, and 
      28 days after injury. Collagen deposition and AT1R expression was measured with 
      Western blot. Serum Hcy, adventitial collagen, and AT1R levels were higher in the 
      HHcy group compared with the control group. Hcy time-dependently induced collagen 
      type 1 and AT1R expression, with the highest induction observed at 48 h. Also, we 
      observed that the AT1R blocker, valsartan, attenuated collagen type 1 and AT1R 
      expression. HHcy exacerbates adventitial remodeling after balloon injury, and the 
      underling mechanisms may be related to AT1R activity.
FAU - Yao, Dan
AU  - Yao D
AD  - Department of Cardiology, Peking University People's Hospital, No. 11 Xizhimen 
      South Street, Xicheng District of Beijing, Beijing 100044, China. 
      yaodan-716@163.com.
FAU - Sun, Ning-Ling
AU  - Sun NL
AD  - Department of Cardiology, Peking University People's Hospital, No. 11 Xizhimen 
      South Street, Xicheng District of Beijing, Beijing 100044, China. nlsun@263.net.
LA  - eng
PT  - Journal Article
DEP - 20141027
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adventitia/*metabolism
MH  - Angioplasty, Balloon/*adverse effects
MH  - Animals
MH  - Carotid Artery Injuries/*etiology/*metabolism/pathology
MH  - Collagen/genetics/*metabolism
MH  - Fibroblasts/drug effects/metabolism
MH  - Gene Expression
MH  - Homocysteine/metabolism/pharmacology
MH  - Hyperhomocysteinemia/*metabolism
MH  - Male
MH  - Rats
MH  - Receptor, Angiotensin, Type 1/genetics/*metabolism
PMC - PMC4264124
EDAT- 2014/10/29 06:00
MHDA- 2015/06/26 06:00
PMCR- 2014/11/01
CRDT- 2014/10/29 06:00
PHST- 2014/07/11 00:00 [received]
PHST- 2014/08/25 00:00 [revised]
PHST- 2014/09/28 00:00 [accepted]
PHST- 2014/10/29 06:00 [entrez]
PHST- 2014/10/29 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - ijms151119487 [pii]
AID - ijms-15-19487 [pii]
AID - 10.3390/ijms151119487 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Oct 27;15(11):19487-98. doi: 10.3390/ijms151119487.