PMID- 25351215
OWN - NLM
STAT- MEDLINE
DCOM- 20150527
LR  - 20181202
IS  - 1002-0098 (Print)
IS  - 1002-0098 (Linking)
VI  - 49
IP  - 8
DP  - 2014 Aug
TI  - [The incidence of oral candidiasis in patients with human immunodeficiency virus 
      infection/acquired immunodeficiency syndrome from Yunnan, China].
PG  - 454-8
AB  - OBJECTIVE: To assess the incidence of oral candidiasis and its influencing 
      factors in patients with human immunodeficiency virus infection/acquired 
      immunodeficiency syndrome (HIV/AIDS). METHODS: An oral examination was conducted 
      in the 1 566 HIV/AIDS patients in the Third Hospital of Kunming from March 2008 
      to September 2012 (M/F: 1 062/504, age range: 0.2 to 84.0 years old). The HIV 
      viral load (HIV- RNA) and peripheral blood CD4 count were respectively analyzed 
      by Bayer Q340 fluorescence signal surveying instrument (bDNA method) and flow 
      cytometry analysis. The information on usage of highly active anti-retroviral 
      (HAART) drugs and transmission of HIV were obtained through questionnaires. The 
      incidence of oral candidiasis in patients with different HIV-RNA levels and CD4 
      count and the use of HAART was analyzed and compared. RESULTS: The total 
      incidence of oral candidosis was 31.0% (486/1 566) and there was no difference in 
      sex. The oral lesions were presented by three types, psudomembranous candidosis 
      (PC), erythematous candidosis (EC) and angular cheilitis (AC), and the morbidity 
      was 13.9% (217/1 566), 17.0% (267/1 566) and 4.9% (77/1 566), respectively. The 
      average level of CD4 count in psudomembranous candidosis, erythematous candidosis 
      and angular cheilitis [81.0 (146.0), 74.0 (152.0) and 69.0 (121.5) cell/microl] 
      showed no significant difference (P > 0.05). The incidence of oral candidiasis in 
      non-HAART and HAART subjects were 36.3% (402/1 107) and 18.3% (84/459), 
      respectively (P = 0.000). The CD4 count and absolute counts of HIV viral load in 
      oral candidiasis patients and non-oral candidiasis patients had significant 
      difference (Z = -10.261, P = 0.000 and Z = -4.762, P = 0.000). CONCLUSIONS: The 
      morbidity of oral candidiasis in HIV/AIDS patients in Yunnan Province was high, 
      including PC, EC and AC and hyperplastic candidosis was not detected. The 
      incidence was related to the degree of immune suppression and HIV viral load.
FAU - Wen, Yan
AU  - Wen Y
AD  - Department of Dentistry, Kunming Medical University Yan An Hospital, Kunming Yan 
      An Hospital, Kunming 650051, China.
FAU - Li, Chengwen
AU  - Li C
FAU - Pei, Junhaoxiang
AU  - Pei J
FAU - Bai, Jinsong
AU  - Bai J
FAU - Yang, Xianghong
AU  - Yang X
FAU - Duan, Kaiwen
AU  - Duan K
AD  - Email: kwduan@aliyun.com.cn.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Kou Qiang Yi Xue Za Zhi
JT  - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese 
      journal of stomatology
JID - 8711066
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*epidemiology
MH  - Acquired Immunodeficiency Syndrome/*complications
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - CD4 Lymphocyte Count
MH  - Candidiasis, Oral/complications/*epidemiology
MH  - Cheilitis
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - HIV Infections
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Middle Aged
MH  - Mouth Diseases
EDAT- 2014/10/30 06:00
MHDA- 2015/05/28 06:00
CRDT- 2014/10/30 06:00
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2015/05/28 06:00 [medline]
PST - ppublish
SO  - Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Aug;49(8):454-8.