PMID- 25351260
OWN - NLM
STAT- MEDLINE
DCOM- 20150529
LR  - 20211021
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 20
DP  - 2014 Oct 29
TI  - Arterial stiffness and carotid intima-media thickness in diabetic peripheral 
      neuropathy.
PG  - 2074-81
LID - 10.12659/MSM.892648 [doi]
AB  - BACKGROUND: We investigated the relationship between peripheral neuropathy and 
      parameters of arterial stiffness and carotid intima media thickness (CIMT) in 
      patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: The study 
      included 161 patients (80 females and 81 males), 69 of whom had peripheral 
      neuropathy. All patients underwent 24-h blood pressure monitoring, and arterial 
      stiffness parameters were measured. The CIMT was measured using B-mode 
      ultrasonography and patients also underwent transthoracic echocardiographic 
      examination. RESULTS: Patients with peripheral neuropathy, compared with those 
      without it, were older (54.68+/-8.35 years vs. 51.04+/-7.89 years; p=0.005) and had 
      T2DM for longer periods (60 vs. 36 months; p=0.004). Glycated hemoglobin (HbA1c) 
      values (8.55+/-1.85 mg/dL vs. 7.30+/-1.51 mg/dL; p<0.001), pulse wave velocity (PWV) 
      (7.74+/-1.14 m/s vs. 7.15+/-1.10 m/s; p=0.001), CIMT (anterior 0.74+/-0.15 mm vs. 
      0.67+/-0.13 mm; p=0.01), and left ventricular mass (LVM) index (98.68+/-26.28 g/m2 
      vs. 89.71+/-19.70 g/m2; p=0.02) were all significantly increased in the group with 
      peripheral neuropathy compared to the group without peripheral neuropathy. We 
      determined that duration of diabetes, HbA1c, and LVM index were predictors of 
      peripheral neuropathy. CONCLUSIONS: A significant relationship was found between 
      diabetic neuropathy and increased PWV, a parameter of arterial stiffness, as well 
      as CIMT, a marker of systemic atherosclerosis. Diabetic peripheral neuropathy may 
      be a determinant of subclinical atherosclerosis in T2DM.
FAU - Avci, Ahmet
AU  - Avci A
AD  - Department of Cardiology, Selcuk University Faculty of Medicine, Konya, Turkey.
FAU - Demir, Kenan
AU  - Demir K
AD  - Department of Cardiology, Selcuk University Faculty of Medicine, Konya, Turkey.
FAU - Kaya, Zeynettin
AU  - Kaya Z
AD  - Department of Cardiology, Mevlana University Faculty of Medicine, Konya, Turkey.
FAU - Marakoglu, Kamile
AU  - Marakoglu K
AD  - Department of Family Medicine, Selcuk University Faculty of Medicine, Konya, 
      Turkey.
FAU - Ceylan, Esra
AU  - Ceylan E
AD  - Department of Family Medicine, Selcuk University Faculty of Medicine, Konya, 
      Turkey.
FAU - Ekmekci, Ahmet Hakan
AU  - Ekmekci AH
AD  - Department of Neurology, Selcuk University Faculty of Medicine, Konya, Turkey.
FAU - Yilmaz, Ahmet
AU  - Yilmaz A
AD  - Department of Cardiology, Selcuk University Faculty of Medicine, Konya, Turkey.
FAU - Demir, Aysegul
AU  - Demir A
AD  - Department of Neurology, Selcuk University Faculty of Medicine, Konya, Turkey.
FAU - Altunkeser, Bulent Behlul
AU  - Altunkeser BB
AD  - Department of Cardiology, Selcuk University Faculty of Medicine, Konya, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141029
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Carotid Arteries/*pathology
MH  - Diabetic Neuropathies/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tunica Intima/*pathology
MH  - *Vascular Stiffness
PMC - PMC4222449
EDAT- 2014/10/30 06:00
MHDA- 2015/05/30 06:00
PMCR- 2014/10/29
CRDT- 2014/10/30 06:00
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2015/05/30 06:00 [medline]
PHST- 2014/10/29 00:00 [pmc-release]
AID - 892648 [pii]
AID - 10.12659/MSM.892648 [doi]
PST - epublish
SO  - Med Sci Monit. 2014 Oct 29;20:2074-81. doi: 10.12659/MSM.892648.