PMID- 25351463
OWN - NLM
STAT- MEDLINE
DCOM- 20150422
LR  - 20220408
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 123
IP  - 2
DP  - 2015 Feb
TI  - Dysregulation of circulating CD4+CXCR5+ T cells in type 2 diabetes mellitus.
PG  - 146-51
LID - 10.1111/apm.12330 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is characterized by a chronic low-grade 
      inflammatory state. Follicular helper T cells (Tfh) play critical roles in 
      inducing B-cell activation and producing various cytokines, whereas circulating 
      CD4+CXCR5+ T cells (CTfh) may act as a counterpart to measure Tfh cell disorders. 
      In this study, we investigated whether Tfh could be involved in the development 
      of T2DM by assessing CTfh in peripheral blood. CTfh and it subtypes were 
      determined by measuring CD3, CD4, CXCR5, CXCR3, and CCR6 in 68 T2DM patients and 
      60 healthy controls using flow cytometry. Results showed that proportion of CTfh 
      in the peripheral CD4+ T cells was significantly increased in T2DM patients 
      (8.5 +/- 0.5%) than in controls (4.5 +/- 0.3%) (p < 0.001). Further study revealed 
      that the balance of CTfh subtypes was greatly dysregulated, in which percentage 
      of Th17 subtype was significantly increased in patients. Investigating the 
      correlation between CTfh and risk factors of T2DM demonstrated that proportion of 
      CTfh were significantly elevated in patients with body mass index (BMI) over 24.0 
      (p = 0.005). Interestingly, patients with abdominal obesity had further increase 
      in CTfh than those without abdominal obesity. This study suggests the involvement 
      of CTfh in T2DM, especially in T2DM-related obesity.
CI  - (c) 2014 APMIS. Published by John Wiley & Sons Ltd.
FAU - Wang, Qijin
AU  - Wang Q
AD  - Department of Endocrinology, Changhai hospital, Second Military Medical 
      University, Shanghai, China.
FAU - Zhai, Xiao
AU  - Zhai X
FAU - Chen, Xiao
AU  - Chen X
FAU - Lu, Jiancan
AU  - Lu J
FAU - Zhang, Yaping
AU  - Zhang Y
FAU - Huang, Qin
AU  - Huang Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141029
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (CCR6 protein, human)
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (CXCR3 protein, human)
RN  - 0 (CXCR5 protein, human)
RN  - 0 (Receptors, CCR6)
RN  - 0 (Receptors, CXCR3)
RN  - 0 (Receptors, CXCR5)
SB  - IM
MH  - Adult
MH  - Aged
MH  - B-Lymphocytes/immunology
MH  - Body Mass Index
MH  - CD3 Complex/blood
MH  - CD4 Antigens/*blood
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Diabetes Mellitus, Type 2/blood/*immunology
MH  - Female
MH  - Humans
MH  - Hypertension/immunology
MH  - Inflammation/immunology
MH  - Lymphocyte Activation/immunology
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/*immunology
MH  - Receptors, CCR6/blood
MH  - Receptors, CXCR3/blood
MH  - Receptors, CXCR5/*blood/immunology
MH  - T-Lymphocytes, Helper-Inducer/*immunology
OTO - NOTNLM
OT  - CD4+CXCR5+ T cells
OT  - Circulating
OT  - obesity
OT  - type 2 diabetes mellitus
EDAT- 2014/10/30 06:00
MHDA- 2015/04/23 06:00
CRDT- 2014/10/30 06:00
PHST- 2014/07/11 00:00 [received]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2015/04/23 06:00 [medline]
AID - 10.1111/apm.12330 [doi]
PST - ppublish
SO  - APMIS. 2015 Feb;123(2):146-51. doi: 10.1111/apm.12330. Epub 2014 Oct 29.