PMID- 25351485
OWN - NLM
STAT- MEDLINE
DCOM- 20161220
LR  - 20181113
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Print)
IS  - 1355-6215 (Linking)
VI  - 21
IP  - 2
DP  - 2016 Mar
TI  - Variations in the stimulus salience of cocaine reward influences drug-associated 
      contextual memory.
PG  - 242-54
LID - 10.1111/adb.12191 [doi]
AB  - Drugs of abuse act as reinforcers because they influence learning and memory 
      processes resulting in long-term memory of drug reward. We have previously shown 
      that mice conditioned by fixed daily dose of cocaine (Fix-C) or daily escalating 
      doses of cocaine (Esc-C) resulted in short- and long-term persistence of drug 
      memory, respectively, suggesting different mechanisms in acquisition of cocaine 
      memory. The present study was undertaken to investigate the differential 
      contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the formation 
      of Fix-C and Esc-C memory in C57BL/6J mice. Training by Esc-C resulted in marked 
      elevation in hippocampal expression of Grin2b mRNA and NR2B protein levels 
      compared with training by Fix-C. The NR2B-containing NMDAR antagonist ifenprodil 
      had similar attenuating effects on acquisition and reconsolidation of Fix-C and 
      Esc-C memory. However, the NMDAR antagonist MK-801 had differential effects: (1) 
      higher doses of MK-801 were required for post-retrieval disruption of 
      reconsolidation of Esc-C memory than Fix-C memory; and (2) pre-retrieval MK-801 
      inhibited extinction of Fix-C memory but it had no effect on Esc-C memory. In 
      addition, blockade of NMDAR downstream signaling pathways also showed 
      differential regulation of Fix-C and Esc-C memory. Inhibition of neuronal nitric 
      oxide synthase attenuated acquisition and disrupted reconsolidation of Fix-C but 
      not Esc-C memory. In contrast, the mitogen-activating extracellular kinase 
      inhibitor SL327 attenuated reconsolidation of Esc-C but not Fix-C memory. These 
      results suggest that NMDAR downstream signaling molecules associated with 
      consolidation and reconsolidation of cocaine-associated memory may vary upon 
      changes in the salience of cocaine reward during conditioning.
CI  - (c) 2014 Society for the Study of Addiction.
FAU - Liddie, Shervin
AU  - Liddie S
AD  - Division of Neuroscience, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Itzhak, Yossef
AU  - Itzhak Y
AD  - Division of Neuroscience, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
AD  - Department of Psychiatry and Behavioral Sciences, University of Miami Miller 
      School of Medicine, Miami, FL, USA.
LA  - eng
GR  - R01 DA026878/DA/NIDA NIH HHS/United States
GR  - R21 DA029404/DA/NIDA NIH HHS/United States
GR  - R01DA026878/DA/NIDA NIH HHS/United States
GR  - R21DA029404/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141028
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (SL 327)
RN  - 3739OQ10IJ (Aminoacetonitrile)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - BD2A56I30W (traxoprodil mesylate)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nos1 protein, mouse)
RN  - I5Y540LHVR (Cocaine)
RN  - R8OE3P6O5S (ifenprodil)
SB  - IM
MH  - Aminoacetonitrile/analogs & derivatives/pharmacology
MH  - Animals
MH  - Cocaine/*pharmacology
MH  - Conditioning, Operant/drug effects
MH  - Dizocilpine Maleate/pharmacology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Male
MH  - Memory/*drug effects
MH  - Mice, Inbred C57BL
MH  - Nitric Oxide Synthase Type I/antagonists & inhibitors
MH  - Piperidines/pharmacokinetics/pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/drug effects
MH  - *Reward
PMC - PMC4412748
MID - NIHMS632171
OTO - NOTNLM
OT  - Addiction
OT  - NR2B
OT  - cocaine
OT  - place preference
OT  - reconsolidation
COIS- The authors declare no conflict of interest.
EDAT- 2014/10/30 06:00
MHDA- 2016/12/21 06:00
PMCR- 2017/03/01
CRDT- 2014/10/30 06:00
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2016/12/21 06:00 [medline]
AID - 10.1111/adb.12191 [doi]
PST - ppublish
SO  - Addict Biol. 2016 Mar;21(2):242-54. doi: 10.1111/adb.12191. Epub 2014 Oct 28.