PMID- 25351914
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20211021
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 25
IP  - 6
DP  - 2015 Nov
TI  - Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent 
      Octodon degus, a Natural Model of Alzheimer's Disease.
PG  - 679-91
LID - 10.1111/bpa.12226 [doi]
AB  - Alzheimer's disease (AD) is the most common neurodegenerative disorder and the 
      leading cause of age-related dementia worldwide. Several models for AD have been 
      developed to provide information regarding the initial changes that lead to 
      degeneration. Transgenic mouse models recapitulate many, but not all, of the 
      features of AD, most likely because of the high complexity of the pathology. In 
      this context, the validation of a wild-type animal model of AD that mimics the 
      neuropathological and behavioral abnormalities is necessary. In previous studies, 
      we have reported that the Chilean rodent Octodon degus could represent a natural 
      model for AD. In the present work, we further describe the age-related 
      neurodegeneration observed in the O. degus brain. We report some 
      histopathological markers associated with the onset progression of AD, such as 
      glial activation, increase in oxidative stress markers, neuronal apoptosis and 
      the expression of the peroxisome proliferative-activated receptor gamma 
      coactivator-1alpha (PGC-1alpha). With these results, we suggest that the O. degus could 
      represent a new model for AD research and a powerful tool in the search for 
      therapeutic strategies against AD.
CI  - (c) 2014 International Society of Neuropathology.
FAU - Inestrosa, Nibaldo C
AU  - Inestrosa NC
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
AD  - Centro UC Sindrome de Down, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
AD  - Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de 
      Magallanes, Punta Arenas, Chile.
AD  - Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, 
      University of New South Wales, Sydney, New South Wales, Australia.
FAU - Rios, Juvenal A
AU  - Rios JA
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Cisternas, Pedro
AU  - Cisternas P
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Tapia-Rojas, Cheril
AU  - Tapia-Rojas C
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Rivera, Daniela S
AU  - Rivera DS
AD  - Departamento de Ecologia and Center of Applied Ecology and Sustainability 
      (CAPES), Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Braidy, Nady
AU  - Braidy N
AD  - Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, 
      University of New South Wales, Sydney, New South Wales, Australia.
FAU - Zolezzi, Juan M
AU  - Zolezzi JM
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad de Tarapaca, Arica, 
      Chile.
FAU - Godoy, Juan A
AU  - Godoy JA
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Carvajal, Francisco J
AU  - Carvajal FJ
AD  - Centro de Envejecimiento y Regeneracion (CARE), Departamento de Biologia Celular 
      y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Ardiles, Alvaro O
AU  - Ardiles AO
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Facultad de Ciencias, 
      Universidad de Valparaiso, Valparaiso, Chile.
FAU - Bozinovic, Francisco
AU  - Bozinovic F
AD  - Centro UC Sindrome de Down, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
AD  - Departamento de Ecologia and Center of Applied Ecology and Sustainability 
      (CAPES), Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
FAU - Palacios, Adrian G
AU  - Palacios AG
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Facultad de Ciencias, 
      Universidad de Valparaiso, Valparaiso, Chile.
FAU - Sachdev, Perminder S
AU  - Sachdev PS
AD  - Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, 
      University of New South Wales, Sydney, New South Wales, Australia.
AD  - Neurosychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20150210
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (Interleukin-6)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.4.3 (Adenylate Kinase)
SB  - IM
MH  - Adenylate Kinase/metabolism
MH  - Aging/*pathology/physiology
MH  - Alzheimer Disease/*pathology/*physiopathology
MH  - Animals
MH  - Apoptosis/physiology
MH  - Astrocytes/pathology/physiology
MH  - Behavior, Animal
MH  - Brain/*pathology/physiopathology
MH  - Disease Models, Animal
MH  - Interleukin-6/metabolism
MH  - Microglia/pathology/physiology
MH  - Neurons/pathology/physiology
MH  - Octodon
MH  - Oxidative Stress/physiology
MH  - Transcription Factors/metabolism
PMC - PMC8029033
OTO - NOTNLM
OT  - Alzheimer' disease
OT  - glial activation
OT  - metabolic sensors
OT  - natural model
OT  - neuronal apoptosis
OT  - oxidative stress
EDAT- 2014/10/30 06:00
MHDA- 2016/08/11 06:00
PMCR- 2015/02/10
CRDT- 2014/10/30 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
PHST- 2015/02/10 00:00 [pmc-release]
AID - BPA12226 [pii]
AID - 10.1111/bpa.12226 [doi]
PST - ppublish
SO  - Brain Pathol. 2015 Nov;25(6):679-91. doi: 10.1111/bpa.12226. Epub 2015 Feb 10.