PMID- 25352367
OWN - NLM
STAT- MEDLINE
DCOM- 20151229
LR  - 20181113
IS  - 1549-8719 (Electronic)
IS  - 1073-9688 (Print)
IS  - 1073-9688 (Linking)
VI  - 22
IP  - 3
DP  - 2015 Apr
TI  - A murine toolbox for imaging the neurovascular unit.
PG  - 168-82
LID - 10.1111/micc.12176 [doi]
AB  - The neurovascular unit (NVU) coordinates many essential functions in the brain 
      including blood flow control, nutrient delivery, and maintenance of BBB 
      integrity. These functions are the result of a cellular and molecular interplay 
      that we are just beginning to understand. Cells of the NVU can now be 
      investigated in the intact brain through the combined use of high-resolution in 
      vivo imaging and non-invasive molecular tools to observe and manipulate cell 
      function. Mouse lines that target transgene expression to cells of the NVU will 
      be of great value in future work. However, a detailed evaluation of target cell 
      specificity and expression pattern within the brain is required for many existing 
      lines. The purpose of this review was to catalog mouse lines available to 
      cerebrovascular biologists and to discuss their utility and limitations in future 
      imaging studies.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Hartmann, David A
AU  - Hartmann DA
AD  - Department of Neurosciences, Medical University of South Carolina, Charleston, 
      South Carolina, USA.
FAU - Underly, Robert G
AU  - Underly RG
FAU - Watson, Ashley N
AU  - Watson AN
FAU - Shih, Andy Y
AU  - Shih AY
LA  - eng
GR  - UL1TR000062/TR/NCATS NIH HHS/United States
GR  - NS085402/NS/NINDS NIH HHS/United States
GR  - GM109040/GM/NIGMS NIH HHS/United States
GR  - UL1 TR000062/TR/NCATS NIH HHS/United States
GR  - T32 GM008716/GM/NIGMS NIH HHS/United States
GR  - R21 NS085402/NS/NINDS NIH HHS/United States
GR  - 2T32GM008716/GM/NIGMS NIH HHS/United States
GR  - P20 GM109040/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Microcirculation
JT  - Microcirculation (New York, N.Y. : 1994)
JID - 9434935
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*cytology
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Molecular Imaging/*methods
MH  - *Neurovascular Coupling
PMC - PMC4393760
MID - NIHMS638771
OTO - NOTNLM
OT  - arteriole
OT  - astrocyte
OT  - capillary
OT  - cerebral blood flow
OT  - cre recombinase
OT  - endothelium
OT  - pericyte
OT  - two-photon microscopy
OT  - vascular smooth muscle
OT  - vasculature
EDAT- 2014/10/30 06:00
MHDA- 2015/12/30 06:00
PMCR- 2016/04/01
CRDT- 2014/10/30 06:00
PHST- 2014/08/30 00:00 [received]
PHST- 2014/10/22 00:00 [accepted]
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2015/12/30 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1111/micc.12176 [doi]
PST - ppublish
SO  - Microcirculation. 2015 Apr;22(3):168-82. doi: 10.1111/micc.12176.