PMID- 25352937
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141029
LR  - 20181113
IS  - 0011-393X (Print)
IS  - 1879-0313 (Electronic)
IS  - 0011-393X (Linking)
VI  - 76
DP  - 2014 Dec
TI  - The Tumor Necrosis Factor-alpha-308 and -238 Polymorphisms and Risk of Hepatocellular 
      Carcinoma for Asian Populations: A Meta-Analysis.
PG  - 70-5
LID - 10.1016/j.curtheres.2014.04.001 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) has been suggested to play a very 
      important role in the development and progression of hepatocellular carcinoma 
      (HCC). Many studies have identified the associations of TNF-alpha-308 and -238 
      polymorphisms with HCC risk, but the results remain controversial. AIM: We 
      conducted this meta-analysis to evaluate the associations between TNF-alpha-308 and 
      -238 polymorphisms and HCC susceptibility. METHODS: PubMed, Embase, and China 
      National Knowledge Infrastructure electronic databases were searched for all 
      articles on associations between TNF-alpha-308 and -238 polymorphisms and HCC risk in 
      Asians through September 30, 2013. Odds ratios (ORs) and their 95% CIs were 
      calculated to assess the strength of this association. RESULTS: A total of 17 
      case-control studies were identified in our meta-analysis. For the TNF-alpha-308 G/A 
      polymorphism, 14 studies containing 3154 cases and 3767 controls were included. 
      Overall, the frequency of the A allele was higher in patients with HCC than in 
      the healthy controls (10.2% vs 7.5%), and the A allele and allele carrier were 
      significantly associated with increased risk of HCC in a random effects model (A 
      vs G: OR = 1.57; 95% CI, 1.22-2.01; P = 0.0004; AA + AG vs GG: OR = 1.62; 95% CI, 
      1.18-2.22; P = 0.003). For the TNF-alpha-238 polymorphism, 10 research articles were 
      identified. No association was found between the TNF-alpha-238 G/A polymorphism and 
      risk of HCC in any genetic models (P > 0.05). The sensitivity analysis further 
      strengthened the overall correlations. CONCLUSIONS: Our meta-analysis proved that 
      the TNF-alpha-308 G/A polymorphism is associated with increased susceptibility to 
      HCC. However, the TNF-alpha-238 G/A polymorphism is not significantly associated with 
      risk of HCC in Asian populations. Further studies with large sample sizes are 
      needed to confirm these associations among other populations.
FAU - Hu, Qing
AU  - Hu Q
AD  - The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , 
      Hangzhou, China.
FAU - Lou, Guo-Guang
AU  - Lou GG
AD  - The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 
      China.
FAU - Liu, Ying-Chao
AU  - Liu YC
AD  - The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , 
      Hangzhou, China.
FAU - Qian, Le
AU  - Qian L
AD  - The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , 
      Hangzhou, China.
FAU - Lv, Bo-Dong
AU  - Lv BD
AD  - The Second Affiliated Hospital, Zhejiang Traditional Chinese Medical University , 
      Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20140927
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC4209508
OTO - NOTNLM
OT  - hepatocellular carcinoma
OT  - meta-analysis
OT  - polymorphism
OT  - tumor necrosis factor-alpha
EDAT- 2014/10/30 06:00
MHDA- 2014/10/30 06:01
PMCR- 2014/09/27
CRDT- 2014/10/30 06:00
PHST- 2014/04/12 00:00 [accepted]
PHST- 2014/10/30 06:00 [entrez]
PHST- 2014/10/30 06:00 [pubmed]
PHST- 2014/10/30 06:01 [medline]
PHST- 2014/09/27 00:00 [pmc-release]
AID - S0011-393X(14)00005-8 [pii]
AID - 10.1016/j.curtheres.2014.04.001 [doi]
PST - epublish
SO  - Curr Ther Res Clin Exp. 2014 Sep 27;76:70-5. doi: 
      10.1016/j.curtheres.2014.04.001. eCollection 2014 Dec.