PMID- 25354496
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20221207
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 52
IP  - 3
DP  - 2015 Dec
TI  - The Physiology of BDNF and Its Relationship with ADHD.
PG  - 1467-1476
LID - 10.1007/s12035-014-8956-6 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central 
      nervous system that plays a critical role in the physiological brain functions 
      via its two independent receptors: tropomyosin-related kinase B (TrkB) and p75, 
      especially in the neurodevelopment. Disrupting of BDNF and its downstream signals 
      has been found in many neuropsychological diseases, including attention-deficit 
      hyperactivity disorder (ADHD), a common mental disorder which is prevalent in 
      childhood. Understanding the physiological functions of BDNF during neural 
      development and its potential relationship with ADHD will help us to elucidate 
      the possible mechanisms of ADHD and to develop therapeutic approaches for this 
      disease. In this review, we summarized the important literatures for the 
      physiological functions of BDNF in the neurodevelopment. We also performed an 
      association study on the functional genetic variation of BDNF and ADHD by a 
      case-control study in the Chinese mainland population and revealed the potential 
      correlation between BDNF and ADHD which needs further research to confirm.
FAU - Liu, De-Yi
AU  - Liu DY
AD  - Department of Pathophysiology, School of Basic Medicine, Institute of Brain 
      Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological 
      Disease, Tongji Medical College, Huazhong University of Science and Technology, 
      Wuhan, 430030, People's Republic of China.
FAU - Shen, Xue-Mei
AU  - Shen XM
AD  - Key Laboratory of Environment and Health, Ministry of Education & Department of 
      Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China.
FAU - Yuan, Fang-Fen
AU  - Yuan FF
AD  - Key Laboratory of Environment and Health, Ministry of Education & Department of 
      Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China.
FAU - Guo, Ou-Yang
AU  - Guo OY
AD  - Department of Pathophysiology, School of Basic Medicine, Institute of Brain 
      Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological 
      Disease, Tongji Medical College, Huazhong University of Science and Technology, 
      Wuhan, 430030, People's Republic of China.
FAU - Zhong, Yan
AU  - Zhong Y
AD  - Department of Child Health Care, Hunan Children's Hospital, Changsha, 410007, 
      People's Republic of China.
FAU - Chen, Jian-Guo
AU  - Chen JG
AD  - Department of Pharmacology, School of Basic Medicine, Institute of Brain 
      Research, Tongji Medical College, Huazhong University of Science and Technology, 
      Wuhan, 430030, People's Republic of China.
FAU - Zhu, Ling-Qiang
AU  - Zhu LQ
AD  - Department of Pathophysiology, School of Basic Medicine, Institute of Brain 
      Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological 
      Disease, Tongji Medical College, Huazhong University of Science and Technology, 
      Wuhan, 430030, People's Republic of China. zhulq1979@gmail.com.
FAU - Wu, Jing
AU  - Wu J
AD  - Key Laboratory of Environment and Health, Ministry of Education & Department of 
      Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430030, People's Republic 
      of China. wujingrlh@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141030
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGFR protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Animals
MH  - Asian People/genetics
MH  - Attention Deficit Disorder with 
      Hyperactivity/epidemiology/*genetics/physiopathology
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/chemistry/deficiency/genetics/*physiology
MH  - Case-Control Studies
MH  - Child
MH  - China/epidemiology
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Humans
MH  - Hyperkinesis/genetics
MH  - Learning Disabilities/genetics
MH  - Mice
MH  - Mice, Knockout
MH  - Mutation, Missense
MH  - Nerve Tissue Proteins/physiology
MH  - Neural Pathways/physiology
MH  - Neurodevelopmental Disorders/physiopathology
MH  - Neurogenesis/*physiology
MH  - Polymorphism, Single Nucleotide
MH  - Rats
MH  - Rats, Transgenic
MH  - Receptor, trkB/physiology
MH  - Receptors, Nerve Growth Factor/physiology
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - ADHD
OT  - BDNF
OT  - Neural development
OT  - Val66Met
EDAT- 2014/10/31 06:00
MHDA- 2016/08/11 06:00
CRDT- 2014/10/31 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2014/10/20 00:00 [accepted]
PHST- 2014/10/31 06:00 [entrez]
PHST- 2014/10/31 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
AID - 10.1007/s12035-014-8956-6 [pii]
AID - 10.1007/s12035-014-8956-6 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Dec;52(3):1467-1476. doi: 10.1007/s12035-014-8956-6. Epub 
      2014 Oct 30.