PMID- 25354497
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20220408
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 52
IP  - 3
DP  - 2015 Dec
TI  - Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and 
      Therapy.
PG  - 1477-1493
LID - 10.1007/s12035-014-8958-4 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of 
      central nervous system (CNS) and is a key molecule in the maintenance of synaptic 
      plasticity and memory storage in hippocampus. However, changes of BDNF level and 
      expression have been reported in the CNS as well as blood of Alzheimer's disease 
      (AD) patients in the last decade, which indicates a potential role of BDNF in the 
      pathogenesis of AD. Therefore, this review aims to summarize the latest progress 
      in the field of BDNF and its biological roles in AD pathogenesis. We will discuss 
      the interaction between BDNF and amyloid beta (Abeta) peptide, the effect of BDNF on 
      synaptic repair in AD, and the association between BDNF polymorphism and AD risk. 
      The most important is, enlightening the detailed biological ability and 
      complicated mechanisms of action of BDNF in the context of AD would provide a 
      future BDNF-related remedy for AD, such as increment in the production or release 
      of endogenous BDNF by some drugs or BDNF mimics.
FAU - Song, Jing-Hui
AU  - Song JH
AD  - Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China.
FAU - Yu, Jin-Tai
AU  - Yu JT
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China. yu-jintai@163.com.
FAU - Tan, Lan
AU  - Tan L
AD  - Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao 
      University, Qingdao, China. dr.tanlan@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141030
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MAPT protein, human)
RN  - 0 (Nootropic Agents)
RN  - 0 (tau Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Alzheimer Disease/epidemiology/metabolism/*physiopathology/therapy
MH  - Amyloid beta-Peptides/metabolism
MH  - Animals
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/agonists/genetics/*physiology
MH  - Caloric Restriction
MH  - Disease Models, Animal
MH  - Exercise Therapy
MH  - Genetic Predisposition to Disease
MH  - Hippocampus/metabolism/physiopathology
MH  - Humans
MH  - Incidence
MH  - Inflammation
MH  - Mice
MH  - Molecular Targeted Therapy
MH  - Neural Stem Cells/transplantation
MH  - Neurogenesis/physiology
MH  - Neuronal Plasticity/physiology
MH  - Nootropic Agents/pharmacology/therapeutic use
MH  - Phosphorylation
MH  - Phytotherapy
MH  - Polymorphism, Single Nucleotide
MH  - Protein Processing, Post-Translational
MH  - Receptor, trkB/drug effects/physiology
MH  - Risk
MH  - tau Proteins/metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Brain-derived neurotrophic factor
OT  - Pathogenesis
OT  - Polymorphism
OT  - Risk
OT  - Therapy
EDAT- 2014/10/31 06:00
MHDA- 2016/08/11 06:00
CRDT- 2014/10/31 06:00
PHST- 2014/08/23 00:00 [received]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2014/10/31 06:00 [entrez]
PHST- 2014/10/31 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
AID - 10.1007/s12035-014-8958-4 [pii]
AID - 10.1007/s12035-014-8958-4 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Dec;52(3):1477-1493. doi: 10.1007/s12035-014-8958-4. Epub 
      2014 Oct 30.