PMID- 25355613
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20220419
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 55
IP  - 3
DP  - 2015 Mar
TI  - Intravenous immunoglobulin-associated thrombosis: is it such a rare event? Report 
      of a pediatric case and of the Quebec Hemovigilance System.
PG  - 571-5
LID - 10.1111/trf.12897 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) is frequently given in autoimmune 
      disorders. Side effects are usually mild but severe complications such as 
      thrombosis may occur. After one patient with IVIG-associated thrombotic 
      complication at Sainte-Justine Hospital, the incidence of serious adverse events 
      (SAEs) reported to the Quebec Hemovigilance System (QHS) was reviewed. STUDY 
      DESIGN AND METHODS: This study was a retrospective review of QHS database of 
      IVIG-related thrombotic complications since 2003, including a case report of a 
      pediatric patient. RESULTS: QHS is one of the rare national hemovigilance systems 
      that have included IVIG reports for almost a decade. Over an extended period of 
      11 years (2003-2013), there have been eight cases of IVIG-related thrombosis, 
      seven in adults and one in the pediatric population (respective rate of 0.06 case 
      and 0.17 case per 100,000 g of IVIG given). The single pediatric case occurred in 
      a 16-year-old female receiving IVIG for severe immune thrombocytopenia. 
      CONCLUSION: Thrombosis after IVIG is a rare though SAE occurring mostly in 
      adults. This underlines the importance of properly reporting IVIG SAEs to improve 
      hemovigilance data and study such rare events.
CI  - (c) 2014 AABB.
FAU - Benadiba, Joy
AU  - Benadiba J
AD  - Department of Paediatric Hematology-Oncology, Sainte Justine Hospital, Montreal, 
      Quebec, Canada.
FAU - Robitaille, Nancy
AU  - Robitaille N
FAU - Lambert, Gilles
AU  - Lambert G
FAU - Itaj, Nawej Karl
AU  - Itaj NK
FAU - Pastore, Yves
AU  - Pastore Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20141029
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Contraceptives, Oral, Hormonal)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Autoimmune Diseases/therapy
MH  - Blood Safety
MH  - Contraceptives, Oral, Hormonal/adverse effects/therapeutic use
MH  - Female
MH  - Headache/etiology
MH  - Humans
MH  - Immunoglobulins, Intravenous/*adverse effects
MH  - Incidence
MH  - Meningitis, Aseptic/etiology
MH  - Menorrhagia/drug therapy/etiology
MH  - Middle Aged
MH  - Prednisone/therapeutic use
MH  - Purpura, Thrombocytopenic, Idiopathic/therapy
MH  - Quebec/epidemiology
MH  - Recurrence
MH  - Retrospective Studies
MH  - Sagittal Sinus Thrombosis/epidemiology/*etiology
MH  - Superior Sagittal Sinus
MH  - Thrombophilia/epidemiology/etiology
MH  - Vision Disorders/etiology
EDAT- 2014/10/31 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/10/31 06:00
PHST- 2014/03/20 00:00 [received]
PHST- 2014/08/12 00:00 [revised]
PHST- 2014/08/14 00:00 [accepted]
PHST- 2014/10/31 06:00 [entrez]
PHST- 2014/10/31 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - 10.1111/trf.12897 [doi]
PST - ppublish
SO  - Transfusion. 2015 Mar;55(3):571-5. doi: 10.1111/trf.12897. Epub 2014 Oct 29.