PMID- 25356056
OWN - NLM
STAT- MEDLINE
DCOM- 20150813
LR  - 20211021
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 20
IP  - 40
DP  - 2014 Oct 28
TI  - Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic 
      fatty liver disease.
PG  - 14950-7
LID - 10.3748/wjg.v20.i40.14950 [doi]
AB  - AIM: To explore the therapeutic role of globular adiponectin (gAd) in high-fat 
      diet/streptozotocin (STZ)-induced type 2 diabetic rats with nonalcoholic fatty 
      liver disease (NAFLD). METHODS: Seven rats were fed a basic diet (normal control 
      group; NC) during the experiment. Experimental rats (14 rats) were given a 
      high-fat diet for 4 wk and were then injected with STZ to induce type 2 diabetes 
      mellitus (T2DM) and NAFLD. Half of the T2DM/NAFLD rats were randomly injected 
      intraperitoneally with gAd for 7 d (gAd-treated group), while the other 7 rats 
      (T2DM/NAFLD group) received 0.9% saline. Plasma biochemical parameters and 
      insulin concentrations were measured. Liver histopathology was examined by 
      hematoxylin-eosin staining. Insulin receptor expression in the liver was analyzed 
      by immunohistochemical staining, Western blot and quantitative real-time reverse 
      transcription polymerase chain reaction analysis. RESULTS: Compared to the 
      control group, the T2DM/NAFLD group had increased levels of glucolipid and 
      decreased levels of insulin. Plasma glucose and lipid levels were decreased in 
      the gAd-treated group, while serum insulin levels increased. The expression of 
      insulin receptor in the T2DM/NAFLD group increased compared with the NC group, 
      and gAd downregulated insulin receptor expression in the livers of T2DM/NAFLD 
      rats. Steatosis of the liver was alleviated in the gAd-treated group compared to 
      the T2DM/NAFLD group (NAS 1.39 +/- 0.51 vs 1.92 +/- 0.51, P < 0.05). CONCLUSION: 
      Globular adiponectin exerts beneficial effects in T2DM rats with NAFLD by 
      promoting insulin secretion, mediating glucolipid metabolism, regulating insulin 
      receptor expression and alleviating hepatic steatosis.
FAU - Ma, Hong
AU  - Ma H
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
FAU - Cui, Fan
AU  - Cui F
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
FAU - Dong, Jing-Jing
AU  - Dong JJ
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
FAU - You, Guo-Ping
AU  - You GP
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
FAU - Yang, Xiang-Jiu
AU  - Yang XJ
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
FAU - Lu, Hua-Dong
AU  - Lu HD
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
FAU - Huang, Yan-Ling
AU  - Huang YL
AD  - Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, 
      Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (RNA, Messenger)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Adiponectin/administration & dosage/*pharmacology
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/blood/chemically induced/*drug therapy/genetics
MH  - Diabetes Mellitus, Type 2/blood/chemically induced/*drug therapy/genetics
MH  - Diet, High-Fat
MH  - Hypoglycemic Agents/administration & dosage/*pharmacology
MH  - Injections, Intraperitoneal
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Liver/*drug effects/metabolism/pathology
MH  - Male
MH  - Non-alcoholic Fatty Liver Disease/blood/*drug therapy/etiology/genetics/pathology
MH  - RNA, Messenger/metabolism
MH  - Rats, Wistar
MH  - Receptor, Insulin/drug effects/genetics/metabolism
MH  - Streptozocin
PMC - PMC4209559
OTO - NOTNLM
OT  - Adiponectin
OT  - Insulin receptor
OT  - Insulin secretion
OT  - Steatosis
EDAT- 2014/10/31 06:00
MHDA- 2015/08/14 06:00
PMCR- 2014/10/28
CRDT- 2014/10/31 06:00
PHST- 2013/12/15 00:00 [received]
PHST- 2014/02/14 00:00 [revised]
PHST- 2014/06/13 00:00 [accepted]
PHST- 2014/10/31 06:00 [entrez]
PHST- 2014/10/31 06:00 [pubmed]
PHST- 2015/08/14 06:00 [medline]
PHST- 2014/10/28 00:00 [pmc-release]
AID - 10.3748/wjg.v20.i40.14950 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2014 Oct 28;20(40):14950-7. doi: 
      10.3748/wjg.v20.i40.14950.