PMID- 25356549
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20191210
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 10
DP  - 2014
TI  - Changes in outer retinal microstructures during six month period in eyes with 
      acute zonal occult outer retinopathy-complex.
PG  - e110592
LID - 10.1371/journal.pone.0110592 [doi]
LID - e110592
AB  - PURPOSE: To study the changes in the outer retinal microstructures during a six 
      month period after the onset of acute zonal occult outer retinopathy 
      (AZOOR)-complex by spectral-domain optical coherence tomography (SD-OCT). 
      METHODS: Seventeen eyes of 17 patients with the AZOOR-complex were studied. The 
      integrity of the external limiting membrane (ELM), ellipsoid zone (EZ; also 
      called the inner/outer segment junction), and interdigitation zone (IDZ; also 
      called the cone outer segment tips) were evaluated in the SD-OCT images obtained 
      at the initial visit and at six months. The three highly reflective bands were 
      divided into three types; continuous, discontinuous, and absent. The integrity of 
      the outer nuclear layer (ONL) was also assessed. RESULTS: Among the three highly 
      reflective bands, the IDZ was most altered at the initial visit and least 
      recovered at six months. Fifteen of 17 eyes (88%) had a recovery of at least one 
      of the three bands at six months in the retinal area where the ONL was intact, 
      and these areas showed an improvement of visual field. Three eyes (18%) had 
      retinal areas where the ONL was absent at the initial visit, and there was no 
      recovery in both the retinal structures and visual fields in these areas. 
      CONCLUSIONS: Our results indicate that more than 85% eyes with AZOOR-complex show 
      some recovery in the microstructures of the outer retina during a six month 
      period if the ONL is intact. We conclude that SD-OCT is a useful method to 
      monitor the changes of the outer retinal microstructure in eyes with the 
      AZOOR-complex.
FAU - Matsui, Yoshitsugu
AU  - Matsui Y
AD  - Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, 
      Japan.
FAU - Matsubara, Hisashi
AU  - Matsubara H
AD  - Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, 
      Japan.
FAU - Ueno, Shinji
AU  - Ueno S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Ito, Yasuki
AU  - Ito Y
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Terasaki, Hiroko
AU  - Terasaki H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kondo, Mineo
AU  - Kondo M
AD  - Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, 
      Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141030
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - Acute zonal occult outer retinopathy
SB  - IM
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recovery of Function
MH  - Retina/*pathology/physiopathology
MH  - Scotoma/*pathology/physiopathology/therapy
MH  - *Tomography, Optical Coherence
MH  - White Dot Syndromes
PMC - PMC4214711
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/10/31 06:00
MHDA- 2015/06/30 06:00
PMCR- 2014/10/30
CRDT- 2014/10/31 06:00
PHST- 2014/05/28 00:00 [received]
PHST- 2014/09/19 00:00 [accepted]
PHST- 2014/10/31 06:00 [entrez]
PHST- 2014/10/31 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
PHST- 2014/10/30 00:00 [pmc-release]
AID - PONE-D-14-22644 [pii]
AID - 10.1371/journal.pone.0110592 [doi]
PST - epublish
SO  - PLoS One. 2014 Oct 30;9(10):e110592. doi: 10.1371/journal.pone.0110592. 
      eCollection 2014.