PMID- 25356653
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20220330
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 10
DP  - 2014
TI  - Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: a marker of 
      advanced disease and electrical myocardial instability.
PG  - e111366
LID - 10.1371/journal.pone.0111366 [doi]
LID - e111366
AB  - BACKGROUND: Myocardial hyperintensity on T2-weighted short-tau inversion recovery 
      (STIR) (HyT2) cardiac magnetic resonance (CMR) images has been demonstrated in 
      patients with hypertrophic cardiomyopathy (HCM) and is considered a sign of acute 
      damage. The aim of the current study was to evaluate the relationship between 
      HyT2 and both a) markers of ventricular electrical instability and b) clinical 
      and CMR parameters. METHODS: Sixty-five patients underwent a thorough clinical 
      examination, consisting of 24-h ECG recording and CMR examination including 
      functional evaluation, T2-STIR images and late gadolinium enhancement (LGE). 
      RESULTS: HyT2 was detected in 27 patients (42%), and subjects with HyT2 showed a 
      greater left ventricle (LV) mass index (p<0.001), lower LV ejection fraction 
      (p = 0.05) and greater extent of LGE (p<0.001) compared to those without HyT2. 
      Twenty-two subjects (34%) presented non-sustained ventricular tachycardia (NSVT) 
      on the 24-h ECG recording, 21 (95%) of whom exhibited HyT2. Based on the logistic 
      regression analysis, HyT2 (odds ratio [OR]: 165, 95% CI 11-2455, p<0.001) and LGE 
      extent (1.1, 1.0-1.3, p<0.001) served as independent predictors of NSVT, while 
      the presence of LGE was not associated with NSVT occurrence (p = 0.49). The 
      presence of HyT2 was associated with lower heart rate variability (p = 0.006) and 
      a higher number of arrhythmic risk factors (p<0.001). CONCLUSIONS: In HCM 
      patients, HyT2 upon CMR examination is associated with more advanced disease and 
      increased arrhythmic burden.
FAU - Todiere, Giancarlo
AU  - Todiere G
AD  - Fondazione G. Monasterio Regione Toscana-National Research Council, Pisa, Italy.
FAU - Pisciella, Lorena
AU  - Pisciella L
AD  - Cardiologia 2 Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy.
FAU - Barison, Andrea
AU  - Barison A
AD  - Fondazione G. Monasterio Regione Toscana-National Research Council, Pisa, Italy.
FAU - Del Franco, Annamaria
AU  - Del Franco A
AD  - Fondazione G. Monasterio Regione Toscana-National Research Council, Pisa, Italy.
FAU - Zachara, Elisabetta
AU  - Zachara E
AD  - Cardiologia 2 Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy.
FAU - Piaggi, Paolo
AU  - Piaggi P
AD  - Endocrinology Unit, University Hospital, Pisa, Italy.
FAU - Re, Federica
AU  - Re F
AD  - Cardiologia 2 Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy.
FAU - Pingitore, Alessandro
AU  - Pingitore A
AD  - Institute of Clinical Physiology, National Research Council, Pisa, Italy.
FAU - Emdin, Michele
AU  - Emdin M
AD  - Fondazione G. Monasterio Regione Toscana-National Research Council, Pisa, Italy.
FAU - Lombardi, Massimo
AU  - Lombardi M
AD  - Multimodality Imaging Section, San Donato, Milano, Italy.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Fondazione G. Monasterio Regione Toscana-National Research Council, Pisa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20141030
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Cardiomyopathy, Hypertrophic/*pathology/*physiopathology
MH  - *Electrophysiological Phenomena
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Tachycardia, Ventricular/physiopathology
PMC - PMC4214734
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/10/31 06:00
MHDA- 2015/12/23 06:00
PMCR- 2014/10/30
CRDT- 2014/10/31 06:00
PHST- 2014/07/15 00:00 [received]
PHST- 2014/10/01 00:00 [accepted]
PHST- 2014/10/31 06:00 [entrez]
PHST- 2014/10/31 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
PHST- 2014/10/30 00:00 [pmc-release]
AID - PONE-D-14-30685 [pii]
AID - 10.1371/journal.pone.0111366 [doi]
PST - epublish
SO  - PLoS One. 2014 Oct 30;9(10):e111366. doi: 10.1371/journal.pone.0111366. 
      eCollection 2014.