PMID- 25358020 OWN - NLM STAT- MEDLINE DCOM- 20150831 LR - 20141104 IS - 1205-7541 (Electronic) IS - 0008-4212 (Linking) VI - 92 IP - 11 DP - 2014 Nov TI - Anti-depressant effect of hesperidin in diabetic rats. PG - 945-52 LID - 10.1139/cjpp-2014-0281 [doi] AB - This study aimed to investigate the anti-depressant effect of hesperidin (Hsp) in streptozotocin (STZ)-induced diabetic rats. Additionally, the effect of Hsp on hyperglycaemia, oxidative stress, inflammation, brain-derived neurotrophic factor (BDNF), and brain monoamines in diabetic rats was also assessed. The Wistar rats in the experimental groups were rendered hyperglycaemic with a single dose of STZ (52.5 mg.(kg body mass)(-1), by intraperitoneal injection). The normal group received the vehicle only. Hyperglycaemic rats were treated with Hsp (25.0, 50.0, or 100.0 mg.(kg body mass)(-1).day(-1), per oral) and fluoxetine (Flu) (5.0 mg.(kg body mass)(-1).day(-1), per oral) 48 h after the STZ injection, for 21 consecutive days. The normal and STZ control groups received the vehicle (distilled water). Behavioral and biochemical parameters were then assessed. When Hsp was administered to the STZ-treated rats, this reversed the STZ-induced increase in immobility duration in the forced swimming test (FST) and attenuated hyperglycaemia, decreased malondialdehyde (MDA), increased reduced glutathione (GSH) decreased interleukin-6 (IL-6), and increased BDNF levels in the brain. Treatment with Hsp attenuated STZ-induced neurochemical alterations, as indicated by increased levels of monoamines in the brain, namely, norepinephrine (NE), dopamine (DA), and serotonin (5-hydroxytryptamine; 5-HT). All of these effects of Hsp were similar to those observed with the established anti-depressant Flu. This study shows that Hsp exerted anti-depressant effect in diabetic rats, which may have been partly mediated by its amelioration of hyperglycaemia as well as its anti-oxidant and anti-inflammatory activities, the enhancement of neurogenesis, and changes in the levels of monoamines in the brain. FAU - El-Marasy, Salma A AU - El-Marasy SA AD - a Department of Pharmacology, National Research Centre, 12622 Cairo, Egypt. FAU - Abdallah, Heba M I AU - Abdallah HM FAU - El-Shenawy, Siham M AU - El-Shenawy SM FAU - El-Khatib, Aiman S AU - El-Khatib AS FAU - El-Shabrawy, Osama A AU - El-Shabrawy OA FAU - Kenawy, Sanaa A AU - Kenawy SA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140919 PL - Canada TA - Can J Physiol Pharmacol JT - Canadian journal of physiology and pharmacology JID - 0372712 RN - 0 (Antidepressive Agents) RN - 0 (Biogenic Monoamines) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Interleukin-6) RN - 01K63SUP8D (Fluoxetine) RN - 4Y8F71G49Q (Malondialdehyde) RN - 5W494URQ81 (Streptozocin) RN - E750O06Y6O (Hesperidin) RN - GAN16C9B8O (Glutathione) SB - IM MH - Animals MH - Antidepressive Agents/pharmacology/*therapeutic use MH - Behavior, Animal/*drug effects MH - Biogenic Monoamines/metabolism MH - Brain-Derived Neurotrophic Factor/metabolism MH - Depression/*drug therapy/psychology MH - Diabetes Mellitus, Experimental/chemically induced/*drug therapy/psychology MH - Fluoxetine/pharmacology/therapeutic use MH - Glutathione/metabolism MH - Hesperidin/pharmacology/*therapeutic use MH - Hyperglycemia/drug therapy/metabolism MH - Inflammation/drug therapy/metabolism MH - Interleukin-6/metabolism MH - Male MH - Malondialdehyde/metabolism MH - Oxidative Stress/drug effects MH - Rats, Wistar MH - Streptozocin OTO - NOTNLM OT - anti-depressant OT - antidepresseur OT - fluoxetine OT - fluoxetine OT - forced swimming test OT - hesperidin OT - hesperidine OT - streptozotocin OT - streptozotocine OT - test de la nage forcee EDAT- 2014/10/31 06:00 MHDA- 2015/09/01 06:00 CRDT- 2014/10/31 06:00 PHST- 2014/10/31 06:00 [entrez] PHST- 2014/10/31 06:00 [pubmed] PHST- 2015/09/01 06:00 [medline] AID - 10.1139/cjpp-2014-0281 [doi] PST - ppublish SO - Can J Physiol Pharmacol. 2014 Nov;92(11):945-52. doi: 10.1139/cjpp-2014-0281. Epub 2014 Sep 19.