PMID- 25358684
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20230921
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Linking)
VI  - 17
IP  - 5
DP  - 2015 Oct
TI  - May BDNF Be Implicated in the Exercise-Mediated Regulation of Inflammation? 
      Critical Review and Synthesis of Evidence.
PG  - 521-39
LID - 10.1177/1099800414555411 [doi]
AB  - INTRODUCTION: Exercise attenuates inflammation and enhances levels of 
      brain-derived neurotrophic factor (BDNF). Exercise also enhances parasympathetic 
      tone, although its role in activating the cholinergic anti-inflammatory pathway 
      is unclear. The physiological pathways of exercise's effect on inflammation are 
      obscure. AIMS: To critically review the evidence on the role of BDNF in the 
      anti-inflammatory effects of exercise and its potential involvement in the 
      cholinergic anti-inflammatory pathway. METHODS: Critical literature review of 
      studies published in MEDLINE, PubMed, CINAHL, Embase, and Cochrane databases. 
      RESULTS: BDNF is critically involved in the bidirectional signaling between 
      immune and neurosensory cells and in the regulation of parasympathetic system 
      responses. BDNF is also intricately involved in the inflammatory response: 
      inflammation induces BDNF production, and, in turn, BDNF exerts pro- and/or 
      anti-inflammatory effects. Although exercise modulates BDNF and its receptors in 
      lymphocytes, data on BDNF's immunoregulatory/anti-inflammatory effects in 
      relation to exercise are scarce. Moreover, BDNF increases cholinergic activity 
      and is modulated by parasympathetic system activation. However, its involvement 
      in the cholinergic anti-inflammatory pathway has not been investigated. 
      CONCLUSION: Converging lines of evidence implicate BDNF in exercise-mediated 
      regulation of inflammation; however, data are insufficient to draw concrete 
      conclusions. We suggest that there is a need to investigate BDNF as a potential 
      modulator/mediator of the anti-inflammatory effects of exercise and of the 
      cholinergic anti-inflammatory pathway during exercise. Such research would have 
      implications for a wide range of inflammatory diseases and for planning targeted 
      exercise protocols.
CI  - (c) The Author(s) 2014.
FAU - Papathanassoglou, Elizabeth D E
AU  - Papathanassoglou ED
AD  - Department of Nursing, Cyprus University of Technology, Limassol, Cyprus 
      e.papathanassoglou@cut.ac.cy.
FAU - Miltiadous, Panagiota
AU  - Miltiadous P
AD  - Department of Nursing, Cyprus University of Technology, Limassol, Cyprus.
FAU - Karanikola, Maria N
AU  - Karanikola MN
AD  - Department of Nursing, Cyprus University of Technology, Limassol, Cyprus.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141029
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Exercise/*physiology
MH  - Humans
MH  - Inflammation/*immunology/*prevention & control
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cholinergic anti-inflammatory pathway
OT  - critical illness
OT  - early progressive mobility
OT  - exercise
OT  - immunity
OT  - inflammation
OT  - parasympathetic nervous system
OT  - physical activity
EDAT- 2014/11/02 06:00
MHDA- 2016/12/15 06:00
CRDT- 2014/11/01 06:00
PHST- 2014/11/01 06:00 [entrez]
PHST- 2014/11/02 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 1099800414555411 [pii]
AID - 10.1177/1099800414555411 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2015 Oct;17(5):521-39. doi: 10.1177/1099800414555411. Epub 2014 
      Oct 29.