PMID- 25359598
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20220331
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 6
IP  - 24
DP  - 2014 Dec 21
TI  - An upconversion nanocomposite for fluorescence resonance energy transfer based 
      cholesterol-sensing in human serum.
PG  - 14792-8
LID - 10.1039/c4nr04380d [doi]
AB  - Upconversion nanophosphors (UCNPs) are extremely useful for analytical 
      applications, since they display a high signal-to-noise ratio, and their 
      photobleaching can be ignored. Herein, a novel upconversion nanocomposite 
      composed of beta-cyclodextrin (beta-CD) derivative modified UCNPs and rhodamine B (RB) 
      was prepared for the detection of cholesterol (Cho). The upconversion 
      luminescence (UCL) emission can serve as a Cho-sensing signal by an effective 
      fluorescence resonance energy transfer (FRET) process, using UCNPs as the donor 
      and RB as the quencher. The sensor for Cho detection in human serum shows 
      excellent sensitivity and selectivity, which has the potential for clinical 
      applications in the analysis of other biological and environmental samples.
FAU - Ding, Yujie
AU  - Ding Y
AD  - State Key Laboratory of Analytical Chemistry for Life Science, School of 
      Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China. 
      jjzhu@nju.edu.cn jianglp@nju.edu.cn.
FAU - Zhu, Hao
AU  - Zhu H
FAU - Zhang, Xiaoxia
AU  - Zhang X
FAU - Gao, Jiangang
AU  - Gao J
FAU - Abdel-Halim, E S
AU  - Abdel-Halim ES
FAU - Jiang, Liping
AU  - Jiang L
FAU - Zhu, Jun-Jie
AU  - Zhu JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141031
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Rhodamines)
RN  - 0 (beta-Cyclodextrins)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - K7G5SCF8IL (rhodamine B)
SB  - IM
MH  - Adult
MH  - Cholesterol/*blood
MH  - Fluorescence Resonance Energy Transfer/*methods
MH  - Humans
MH  - Nanocomposites/*analysis/*chemistry
MH  - Reproducibility of Results
MH  - Rhodamines/*blood/chemistry
MH  - Sensitivity and Specificity
MH  - beta-Cyclodextrins/*blood/chemistry
EDAT- 2014/11/02 06:00
MHDA- 2015/10/09 06:00
CRDT- 2014/11/01 06:00
PHST- 2014/11/01 06:00 [entrez]
PHST- 2014/11/02 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - 10.1039/c4nr04380d [doi]
PST - ppublish
SO  - Nanoscale. 2014 Dec 21;6(24):14792-8. doi: 10.1039/c4nr04380d. Epub 2014 Oct 31.