PMID- 25359626
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20220330
IS  - 1297-9716 (Electronic)
IS  - 0928-4249 (Print)
IS  - 0928-4249 (Linking)
VI  - 45
IP  - 1
DP  - 2014 Oct 31
TI  - Bovine herpesvirus glycoprotein D: a review of its structural characteristics and 
      applications in vaccinology.
PG  - 111
LID - 10.1186/s13567-014-0111-x [doi]
LID - 111
AB  - The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and 
      -5), two important pathogens of cattle, is a major component of the virion and 
      plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is 
      essential for virus penetration into permissive cells and thus is a major target 
      for virus neutralizing antibodies during infection. In view of its role in the 
      induction of protective immunity, gD has been tested in new vaccine development 
      strategies against both viruses. Subunit, DNA and vectored vaccine candidates 
      have been developed using this glycoprotein as the primary antigen, demonstrating 
      that gD has the capacity to induce robust virus neutralizing antibodies and 
      strong cell-mediated immune responses, as well as protection from clinical 
      symptoms, in target species. This review highlights the structural and functional 
      characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as 
      well as its role in viral entry and interactions with host cell receptors. 
      Furthermore, the interactions of gD with the host immune system are discussed. 
      Finally, the application of this glycoprotein in new vaccine design is reviewed, 
      taking its structural and functional characteristics into consideration.
FAU - Alves Dummer, Luana
AU  - Alves Dummer L
AD  - Laboratorio de Bacteriologia, Nucleo de Biotecnologia, Centro de Desenvolvimento 
      Tecnologico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, 
      96010-900, Brazil. dummer@gmail.com.
FAU - Pereira Leivas Leite, Fabio
AU  - Pereira Leivas Leite F
AD  - Laboratorio de Bacteriologia, Nucleo de Biotecnologia, Centro de Desenvolvimento 
      Tecnologico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, 
      96010-900, Brazil. fabio_leite@ufpel.edu.br.
FAU - van Drunen Littel-van den Hurk, Sylvia
AU  - van Drunen Littel-van den Hurk S
AD  - Microbiology and Immunology, College of Medicine, University of Saskatchewan, 
      Saskatoon, Saskatchewan, S7N 5E3, Canada. sylvia.vandenhurk@usask.ca.
AD  - VIDO-Intervac, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, 
      Canada. sylvia.vandenhurk@usask.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141031
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Herpesvirus 1, Bovine/immunology/*physiology
MH  - Herpesvirus 1, Human/immunology/*physiology
MH  - Herpesvirus 2, Human/immunology/*physiology
MH  - Herpesvirus 5, Bovine/immunology/*physiology
MH  - Humans
MH  - Viral Envelope Proteins/chemistry/*genetics
MH  - Viral Vaccines/*immunology
PMC - PMC4252008
EDAT- 2014/11/02 06:00
MHDA- 2016/02/05 06:00
PMCR- 2014/10/31
CRDT- 2014/11/01 06:00
PHST- 2014/07/06 00:00 [received]
PHST- 2014/10/09 00:00 [accepted]
PHST- 2014/11/01 06:00 [entrez]
PHST- 2014/11/02 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
PHST- 2014/10/31 00:00 [pmc-release]
AID - s13567-014-0111-x [pii]
AID - 111 [pii]
AID - 10.1186/s13567-014-0111-x [doi]
PST - epublish
SO  - Vet Res. 2014 Oct 31;45(1):111. doi: 10.1186/s13567-014-0111-x.