PMID- 25362619
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20141103
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 27
IP  - 6
DP  - 2014 Nov
TI  - Protective effect of Cucurbita pepo fruit peel against CCl4 induced neurotoxicity 
      in rat.
PG  - 1967-73
AB  - Cucurbita pepo is a common vegetable used all over the world. In folk medicine it 
      is used in gastroenteritis, hepatorenal and in brain anomalies. In the present 
      study, protective effect of Cucurbita pepo fruit peel against CCl4-induced 
      neurotoxicity in rats was investigated. In this study, 36 Sprague-Dawley female 
      rats (190+/-15 g) were randomly divided into 6 groups of 6 rats each. Group I was 
      given 1 ml/kg bw (body weight) of corn oil intraperotoneally (i.p); Group II, III 
      and IV were treated with 20% CCl4 in corn oil (1ml/kg bw i.p.). However, animals 
      of Group III and IV were also treated with CPME (methanol extract of C. pepo 
      fruit peel) at 200 and 400mg/kg bw respectively. Animals of Group V and VI were 
      administered only with CPME at 200 and 400mg/kg bw respectively. These treatments 
      were administered 3 days a week for two weeks. Administration of CCl4 cause acute 
      neurotoxicity as depicted by significant depletion (p<0.05) in the activities of 
      antioxidant enzymes; catalase, superoxide dismutase, peroxidase, glutathione 
      reductase, glutathione-S-transferase, glutathione peroxidase, quinone reductase, 
      while enhanced the gamma-glutamyl transferase level in brain samples. CCl4 
      intoxication decreased the reduced glutathione (GSH) level whereas markedly 
      (p<0.05) enhanced lipid peroxidation in brain samples. Co-treatment of CPME 
      significantly (p<0.05) protected the brain tissues against CCl4 constituted 
      injuries by restoring activities of antioxidant enzymes and ameliorated lipid 
      peroxidation in a dose dependent fashion. These neuroprotective effects might be 
      due to the presence of antioxidant constituents.
FAU - Zaib, Sania
AU  - Zaib S
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University, Islamabad, Pakistan.
FAU - Khan, Muhammad Rashid
AU  - Khan MR
AD  - Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam 
      University, Islamabad, Pakistan.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - EC 1.11.1.6 (Catalase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Carbon Tetrachloride
MH  - Catalase/metabolism
MH  - *Cucurbita
MH  - Female
MH  - Fruit
MH  - Glutathione/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2014/11/05 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/11/03 06:00
PHST- 2014/11/03 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PST - ppublish
SO  - Pak J Pharm Sci. 2014 Nov;27(6):1967-73.