PMID- 25363066
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20151030
IS  - 1556-9535 (Electronic)
IS  - 1556-9527 (Linking)
VI  - 34
IP  - 4
DP  - 2015
TI  - Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform 
      layer complex.
PG  - 282-5
LID - 10.3109/15569527.2014.975240 [doi]
AB  - PURPOSE: The aim of this study is to show the effects of smoking on retina 
      layers, especially retina nerve fiber layer (RNFL) and ganglion cell-inner 
      plexiform layer complex (GCIPL). MATERIALS AND METHODS: Participants smoking for 
      more than 10 years at least 1 pack of cigarettes a day and a control group, both 
      including participants between ages of 20 and 50 years with no other systemic or 
      ocular diseases were studied. After normality tests, an independent sample t test 
      was used to analyze the differences in age, sex, spherical equivalent (SE), 
      intraocular pressure (IOP), axial length (AL), GCIPL and RNFL values between the 
      groups. RESULTS: There were 44 participants in each group. There were 32 (62.5%) 
      men and 12(37.5%) women in smokers and 36 (77.88%) men and 8 (22.22%) women in 
      control group. Mean ages were 39.85 +/- 8.41 and 38.66 +/- 10.47 years, mean 
      spherical equivalent (SE) values were -0.15 +/- 0.4 and 0 +/- 0.29 dioptries in 
      smokers and control groups, respectively. The IOP, AXL, GCIPL and RNFL values 
      were 17.58 +/- 3.41 mmHg, 23.69 +/- 0.56 mm, 84.3 +/- 5.83 mum and 92.3 +/- 3.51 mum in the 
      smokers group and 18.5 +/- 2.91 mmHg, 23.45 +/- 0.72 mm, 86.11 +/- 8.02 mum and 
      97.66 +/- 8.23 mum in the control group. The inferior, superior, nasal and temporal 
      values of RNFL quadrants were 123.18 +/- 26.14, 117.05 +/- 5.51, 64.95 +/- 8.67 and 
      63.5 +/- 6.88 mum in the smokers group and 130.81 +/- 11.8, 123.55 +/- 11.03, 
      72.44 +/- 9.84 and 58.44 +/- 7.48 mum in the control group. There were no significant 
      difference of age, sex, SE, IOP, AXL and GCIPL values between the smokers and 
      control groups (p > 0.05). The mean RNFL was significantly thinner in the smokers 
      group compared to controls (p = 0.03, independent t test). Inferior and superior 
      quadrants of RNFL decreased in smokers group (p = 0.01 and p = 0.03, 
      respectively) but temporal and nasal quadrants did not seem to be changed 
      (p = 0.96 and p = 0.07, respectively). DISCUSSION: Smoking may affect RNFL 
      thickness but not GCIPL.
FAU - Dervisogullari, Mehmet Serdar
AU  - Dervisogullari MS
AD  - a Department of Ophthalmology , Medical School, Turgut Ozal University , Ankara , 
      Turkey.
FAU - Totan, Yuksel
AU  - Totan Y
AD  - a Department of Ophthalmology , Medical School, Turgut Ozal University , Ankara , 
      Turkey.
FAU - Tenlik, Aylin
AU  - Tenlik A
AD  - a Department of Ophthalmology , Medical School, Turgut Ozal University , Ankara , 
      Turkey.
FAU - Yuce, Aslihan
AU  - Yuce A
AD  - a Department of Ophthalmology , Medical School, Turgut Ozal University , Ankara , 
      Turkey.
FAU - Guler, Emre
AU  - Guler E
AD  - a Department of Ophthalmology , Medical School, Turgut Ozal University , Ankara , 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20141103
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/drug effects/*pathology
MH  - Nicotine/toxicity
MH  - Optic Nerve/drug effects/*pathology
MH  - Prospective Studies
MH  - Retina/drug effects/*pathology
MH  - Retinal Ganglion Cells/drug effects/*pathology
MH  - Smoking/*adverse effects
MH  - Tomography, Optical Coherence
MH  - Young Adult
OTO - NOTNLM
OT  - Ganglion cell
OT  - inner plexiform layer complex
OT  - retinal nerve fiber layer
OT  - smoking
EDAT- 2014/11/05 06:00
MHDA- 2016/09/08 06:00
CRDT- 2014/11/04 06:00
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
AID - 10.3109/15569527.2014.975240 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2015;34(4):282-5. doi: 10.3109/15569527.2014.975240. Epub 
      2014 Nov 3.