PMID- 25363345
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20211203
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 56
IP  - 7
DP  - 2015 Jul
TI  - Histamine-releasing factor/translationally controlled tumor protein plays a role 
      in induced cell adhesion, apoptosis resistance and chemoresistance in non-Hodgkin 
      lymphomas.
PG  - 2153-61
LID - 10.3109/10428194.2014.981173 [doi]
AB  - Mounting evidence has proved that cellular adhesion confers resistance to 
      chemotherapy in multiple lymphomas. The molecular mechanism underlying cell 
      adhesion-mediated drug resistance (CAM-DR) is, however, poorly understood. In 
      this study, we investigated the expression and biologic function of 
      histamine-releasing factor (HRF) in non-Hodgkin lymphomas (NHLs). Clinically, by 
      immunohistochemistry analysis we observed obvious up-regulation of HRF in NHLs 
      including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and 
      natural killer (NK)/T-cell lymphoma. Functionally, overexpression and knockdown 
      of HRF demonstrated the antiapoptotic effect of HRF in NHL cells, which may be 
      associated with activation of the p-CREB/BCL-2 signaling pathway. Moreover, cell 
      adhesion assay demonstrated that adhesion to fibronectin (FN) or HS-5 
      up-regulated HRF expression, while knockdown of HRF resulted in decreased cell 
      adhesion, which led to reversed CAM-DR. Our finding supports the role of HRF in 
      NHL cell apoptosis, adhesion and drug resistance, and may provide a clinical 
      therapeutic target for CAM-DR in NHL.
FAU - He, Song
AU  - He S
AD  - Department of Oncology, Affiliated Cancer Hospital of Nantong University, Jiangsu 
      Province Key Laboratory for Inflammation and Molecular Drug Target , Nantong, 
      Jiangsu , China.
FAU - Huang, Yuejiao
AU  - Huang Y
FAU - Wang, Yuchan
AU  - Wang Y
FAU - Tang, Jie
AU  - Tang J
FAU - Song, Yan
AU  - Song Y
FAU - Yu, Xiafei
AU  - Yu X
FAU - Ma, Jing
AU  - Ma J
FAU - Wang, Shitao
AU  - Wang S
FAU - Yin, Haibing
AU  - Yin H
FAU - Li, Qiuyue
AU  - Li Q
FAU - Ji, Lili
AU  - Ji L
FAU - Xu, Xiaohong
AU  - Xu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150127
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Tumor Protein, Translationally-Controlled 1)
SB  - IM
MH  - *Apoptosis
MH  - Biomarkers, Tumor/antagonists & inhibitors/genetics/*metabolism
MH  - Blotting, Western
MH  - *Cell Adhesion
MH  - Cell Proliferation
MH  - *Drug Resistance, Neoplasm
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lymphoma, Non-Hodgkin/*drug therapy/metabolism/*pathology
MH  - RNA, Small Interfering/genetics
MH  - Signal Transduction
MH  - Tumor Cells, Cultured
MH  - Tumor Protein, Translationally-Controlled 1
OTO - NOTNLM
OT  - CAM-DR
OT  - HRF
OT  - Non-Hodgkin lymphoma (NHL)
OT  - apoptosis
OT  - cell adhesion
OT  - immunohistochemistry
EDAT- 2014/11/05 06:00
MHDA- 2016/05/06 06:00
CRDT- 2014/11/04 06:00
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
AID - 10.3109/10428194.2014.981173 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2015 Jul;56(7):2153-61. doi: 10.3109/10428194.2014.981173. Epub 
      2015 Jan 27.