PMID- 25364476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1925-4067 (Print)
IS  - 1925-4075 (Electronic)
IS  - 1925-4067 (Linking)
VI  - 3
IP  - 6
DP  - 2013 Dec 1
TI  - Identification of death receptors DR4 and DR5 in HTB-12 astrocytoma cell lines 
      and determination of TRAIL sensitivity.
PG  - 20-26
AB  - Astrocytomas are tumors which arise from astrocytes, cells that form the 
      blood-brain barrier. There are very few drugs that successfully treat brain 
      tumors. In this study, the cytotoxic effects on the HTB-12 astrocytoma cell line 
      by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) were studied. 
      The presence of the TRAIL receptors, Death receptor 4 (DR4) and Death receptor 5 
      (DR5), were detected in HTB-12 cells by Enzyme-Linked Immunosorbent Assay 
      (ELISA). Cytotoxicity assay by Trypan Blue Exclusion Method showed effective cell 
      killing by TRAIL treatment. Thus, the presence of death receptors and TRAIL 
      efficacy raises the therapeutic potential for this type of brain tumor.
FAU - Riddick, Elenia
AU  - Riddick E
AD  - Department of Biological and Pharmaceutical Sciences, Elizabeth City State 
      University campus of The University of North Carolina, Elizabeth City, NC / USA.
FAU - Evans, Shavonda
AU  - Evans S
AD  - Department of Biological and Pharmaceutical Sciences, Elizabeth City State 
      University campus of The University of North Carolina, Elizabeth City, NC / USA.
FAU - Rousch, Jeffrey
AU  - Rousch J
AD  - Department of Biological and Pharmaceutical Sciences, Elizabeth City State 
      University campus of The University of North Carolina, Elizabeth City, NC / USA.
FAU - Gwebu, Ephraim
AU  - Gwebu E
AD  - Department of Biological and Pharmaceutical Sciences, Elizabeth City State 
      University campus of The University of North Carolina, Elizabeth City, NC / USA.
FAU - Banerjee, Hirendra Nath
AU  - Banerjee HN
AD  - Department of Biological and Pharmaceutical Sciences, Elizabeth City State 
      University campus of The University of North Carolina, Elizabeth City, NC / USA.
LA  - eng
GR  - R25 GM082808/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - Canada
TA  - J Solid Tumors
JT  - Journal of solid tumors
JID - 101631764
PMC - PMC4214680
MID - NIHMS574107
OTO - NOTNLM
OT  - Astrocytes
OT  - Astrocytoma
OT  - Death receptors
OT  - TRAIL
EDAT- 2014/11/05 06:00
MHDA- 2014/11/05 06:01
PMCR- 2014/10/30
CRDT- 2014/11/04 06:00
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2014/11/05 06:01 [medline]
PHST- 2014/10/30 00:00 [pmc-release]
AID - 10.5430/jst.v3n6p20 [doi]
PST - ppublish
SO  - J Solid Tumors. 2013 Dec 1;3(6):20-26. doi: 10.5430/jst.v3n6p20.