PMID- 25364679
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141103
LR  - 20240321
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 18
IP  - 6
DP  - 2014 Nov
TI  - Bone mineral density and factors influencing it in Asian Indian population with 
      type 2 diabetes mellitus.
PG  - 831-7
LID - 10.4103/2230-8210.140268 [doi]
AB  - OBJECTIVE: To assess bone mineral density (BMD) in type 2 diabetes mellitus 
      (T2DM) patients and its relation, if any, to clinical, hormonal and metabolic 
      factors. MATERIALS AND METHODS: A prospective evaluation of 194 T2DM patients (97 
      men and 97 women) was carried out. BMD was done with dual energy X-ray 
      absorptiometry (DXA) at the lumbar spine and total hip. Physical activity, 
      nutritional intake and sunlight exposure were calculated. Biochemical and 
      hormonal tests included serum 25 hydroxy vitamin D [25(OH) D], parathyroid 
      hormone, estrogen, testosterone and urinary calcium-creatinine ratio. 
      Glycosylated hemoglobin and complete lipid profiles were done in patients with 
      diabetes. Five hundred and seventy one non-diabetic controls (262 males and 309 
      females) were evaluated for BMD alone. RESULTS: BMD was normal (Z score > -2) in 
      156 (80.5%) and low (Z score </= -2) in 38 (19.5%) patients in the diabetes study 
      group. BMD in the diabetes group was significantly higher than the control group 
      in both sexes at the hip and spine. The difference was no longer significant on 
      analysis of a BMI matched control subgroup. Weight and BMI showed significant 
      correlation to BMD. Duration of T2DM, degree of glycemic control, use of drugs 
      like statins and thiazolidinediones, 25(OH) D levels, calcium intake, sunlight 
      exposure and physical activity did not significantly affect BMD in this cohort of 
      individuals with diabetes. CONCLUSIONS: Bone mineral density of Asian Indian T2DM 
      subjects was similar to that of healthy volunteers in this study.
FAU - Kamalanathan, Sadishkumar
AU  - Kamalanathan S
AD  - Department of Endocrinology, JIPMER, Puducherry, India.
FAU - Nambiar, Vimal
AU  - Nambiar V
AD  - Consultant of Endocrinology, MIMS Hospital, Calicut, India.
FAU - Shivane, Vyankatesh
AU  - Shivane V
AD  - Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, 
      India.
FAU - Bandgar, Tushar
AU  - Bandgar T
AD  - Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, 
      India.
FAU - Menon, Padmavathy
AU  - Menon P
AD  - Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, 
      India.
FAU - Shah, Nalini
AU  - Shah N
AD  - Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC4192990
OTO - NOTNLM
OT  - Asian Indian
OT  - bone mineral density
OT  - obesity
OT  - type 2 diabetes mellitus
OT  - vitamin D deficiency
COIS- Conflict of Interest: None declared.
EDAT- 2014/11/05 06:00
MHDA- 2014/11/05 06:01
PMCR- 2014/11/01
CRDT- 2014/11/04 06:00
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2014/11/05 06:01 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - IJEM-18-831 [pii]
AID - 10.4103/2230-8210.140268 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2014 Nov;18(6):831-7. doi: 10.4103/2230-8210.140268.