PMID- 25364723
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141103
LR  - 20220330
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 2
DP  - 2014
TI  - Stem cell transplantation improves aging-related diseases.
PG  - 16
LID - 10.3389/fcell.2014.00016 [doi]
LID - 16
AB  - Aging is a complex process of damage accumulation, and has been viewed as 
      experimentally and medically intractable. The number of patients with 
      age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, 
      Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and cancer has 
      increased recently. Aging-related diseases are related to a deficiency of the 
      immune system, which results from an aged thymus and bone marrow cells. Intra 
      bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat 
      intractable diseases. This review summarizes findings that IBM-BMT can improve 
      and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal 
      models.
FAU - Ikehara, Susumu
AU  - Ikehara S
AD  - Department of Stem Cell Disorders, Kansai Medical University Hirakata, Osaka, 
      Japan.
FAU - Li, Ming
AU  - Li M
AD  - Department of Stem Cell Disorders, Kansai Medical University Hirakata, Osaka, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140502
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC4206983
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - aging-related diseases
OT  - bone marrow transplantation
OT  - osteoporosis
OT  - type 2 diabetes mellitus
EDAT- 2014/11/05 06:00
MHDA- 2014/11/05 06:01
PMCR- 2014/01/01
CRDT- 2014/11/04 06:00
PHST- 2014/02/11 00:00 [received]
PHST- 2014/04/14 00:00 [accepted]
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2014/11/05 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2014.00016 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2014 May 2;2:16. doi: 10.3389/fcell.2014.00016. eCollection 
      2014.