PMID- 25364730
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141103
LR  - 20211021
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 2
DP  - 2014
TI  - In silico discovery of novel transcription factors regulated by mTOR-pathway 
      activities.
PG  - 23
LID - 10.3389/fcell.2014.00023 [doi]
LID - 23
AB  - The mammalian target of rapamycine (mTOR) pathway is a key regulator of cellular 
      growth, development, and ageing, and unraveling its control is essential for 
      understanding life and death of biological organisms. A motif-discovery workbench 
      including nine tools was used to identify transcription factors involved in five 
      basic (Insulin, MAPK, VEGF, Hypoxia, and mTOR core) activities of the mTOR 
      pathway. Discovered transcription factors are classified as "process-specific" or 
      "pathway-ubiquitous" with highlights toward their regulating/regulated activities 
      within the mTOR pathway. Our transcription regulation results will facilitate 
      further research on investigating the control mechanism in mTOR pathway.
FAU - Jablonska, Agnieszka
AU  - Jablonska A
AD  - Faculty of Biotechnology and Food Sciences, Lodz University of Technology Lodz, 
      Poland.
FAU - Polouliakh, Natalia
AU  - Polouliakh N
AD  - Fundamental Research Laboratories, Sony Computer Science Laboratories Inc. Tokyo, 
      Japan ; Systems Biology Institute Tokyo, Japan ; Graduate School of Medicine, 
      Yokohama City University Yokohama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140603
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC4206986
OTO - NOTNLM
OT  - bioinformatic tools and databases
OT  - cell signaling
OT  - mTOR pathway
OT  - orthologous genes
OT  - transcription factors
EDAT- 2014/11/05 06:00
MHDA- 2014/11/05 06:01
PMCR- 2014/01/01
CRDT- 2014/11/04 06:00
PHST- 2014/04/01 00:00 [received]
PHST- 2014/05/09 00:00 [accepted]
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2014/11/05 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2014.00023 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2014 Jun 3;2:23. doi: 10.3389/fcell.2014.00023. eCollection 
      2014.