PMID- 25364946 OWN - NLM STAT- MEDLINE DCOM- 20150512 LR - 20230921 IS - 1557-7708 (Electronic) IS - 1075-5535 (Linking) VI - 20 IP - 11 DP - 2014 Nov TI - Effects of weekly one-hour Hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders: an eight-week randomized controlled trial. PG - 823-30 LID - 10.1089/acm.2014.0205 [doi] AB - OBJECTIVE: To examine the effects of Hatha yoga therapy on resilience, brain-derived neurotrophic factor (BDNF) levels, and salivary alpha amylase (SAA) activity in patients with schizophrenia-spectrum disorders. DESIGN AND PARTICIPANTS: Single-blinded, randomized controlled study in which outpatients with schizophrenia or related psychotic disorders (according to International Classification of Diseases, 10th Revision) were randomly assigned to a yoga or a control group. SETTING: November 2012-April 2013 at Yamanashi Prefectural Kita Hospital, Japan. INTERVENTIONS: In the yoga group, patients received weekly 1-hour Hatha yoga sessions, in addition to regular treatment, for 8 weeks. Those in the control group underwent regular treatment, which included a daycare rehabilitation program. OUTCOME MEASURES: Assessments included the 25-item Resilience Scale (RS), Positive and Negative Syndrome Scale (PANSS), plasma and salivary BDNF level, and SAA activity. RESULTS: Fifty patients participated (25 in each group; mean age+/-standard deviation, 50.9+/-11.3 years; mean duration of illness, 25.0+/-10.3 years; mean total PANSS score, 78.2+/-17.3). No significant differences in changes in any variable from baseline to week 8 were found between the two groups (changes in the yoga group versus the control group: RS score, -1.6+/-19.9 versus 0.3+/-17.2; PANSS score, 0.5+/-12.0 versus 5.0+/-15.6; plasma BDNF, 41.6+/-377.0 pg/dl versus 73.4+/-346.0 pg/dl; SAA, -26.2+/-72.6 kU/l versus -13.8+/-68.0 kU/l, respectively). CONCLUSIONS: Adjunct yoga therapy showed no positive changes in resilience level or stress markers. Duration and intensity of yoga sessions and the focus on patients with chronic illness may explain the negative observations in light of past positive evidence regarding yoga therapy. FAU - Ikai, Saeko AU - Ikai S AD - 1 Department of Neuropsychiatry, Keio University School of Medicine , Tokyo, Japan . FAU - Suzuki, Takefumi AU - Suzuki T FAU - Uchida, Hiroyuki AU - Uchida H FAU - Saruta, Juri AU - Saruta J FAU - Tsukinoki, Keiichi AU - Tsukinoki K FAU - Fujii, Yasuo AU - Fujii Y FAU - Mimura, Masaru AU - Mimura M LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20141103 PL - United States TA - J Altern Complement Med JT - Journal of alternative and complementary medicine (New York, N.Y.) JID - 9508124 SB - IM MH - Adult MH - Analysis of Variance MH - Female MH - Humans MH - Male MH - Middle Aged MH - Quality of Life/psychology MH - *Resilience, Psychological MH - Schizophrenia/*therapy MH - Schizophrenic Psychology MH - Single-Blind Method MH - Stress, Psychological/psychology/*therapy MH - Treatment Outcome MH - *Yoga EDAT- 2014/11/05 06:00 MHDA- 2015/05/13 06:00 CRDT- 2014/11/04 06:00 PHST- 2014/11/04 06:00 [entrez] PHST- 2014/11/05 06:00 [pubmed] PHST- 2015/05/13 06:00 [medline] AID - 10.1089/acm.2014.0205 [doi] PST - ppublish SO - J Altern Complement Med. 2014 Nov;20(11):823-30. doi: 10.1089/acm.2014.0205. Epub 2014 Nov 3.