PMID- 25365295
OWN - NLM
STAT- MEDLINE
DCOM- 20151014
LR  - 20220321
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 19
IP  - 11
DP  - 2014 Oct 31
TI  - Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well 
      as five organosulfur compounds.
PG  - 17697-714
LID - 10.3390/molecules191117697 [doi]
AB  - The anti-neuroinflammatory capacities of raw and steamed garlic extracts as well 
      as five organosulfur compounds (OSCs) were examined in lipopolysaccharide 
      (LPS)-stimulated BV2 microglia. According to those results, steaming pretreatment 
      blocked the formation of alliinase-catalyzed OSCs such as allicin and diallyl 
      trisulfide (DATS) in crushed garlic. Raw garlic, but not steamed garlic, 
      dose-dependently attenuated the production of LPS-induced nitric oxide (NO), 
      interleukin-1beta (IL-1beta), tumor necrosis factor (TNF)-alpha, and monocyte 
      chemoattractant protein-1 (MCP-1). DATS and diallyl disulfide at 200 and 400 muM, 
      respectively, displayed significant anti-neuroinflammatory activity. Meanwhile, 
      even at 1 mM, diallyl sulfide, S-allyl cysteine and alliin did not display such 
      activity. Inhibition of nuclear factor-kappaB activation was the mechanism underlying 
      this protective effect of raw garlic and DATS. Analysis results indicated that 
      the anti-neuroinflammatory capacity of raw garlic is due to the alliin-derived 
      OSCs. Importantly, DATS is a highly promising therapeutic candidate for treating 
      inflammation-related neurodegenerative diseases.
FAU - Ho, Su-Chen
AU  - Ho SC
AD  - Department of Food Science, Yuanpei University, No. 306, Yuanpei Street, Hsinchu 
      300, Taiwan. sche@mail.ypu.edu.tw.
FAU - Su, Min-Sheng
AU  - Su MS
AD  - Department of Food Science, Yuanpei University, No. 306, Yuanpei Street, Hsinchu 
      300, Taiwan. mssu@mail.ypu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141031
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Allyl Compounds)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Disulfides)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Sulfides)
RN  - 0 (Sulfur Compounds)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0ZO1U5A3XX (diallyl trisulfide)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 5HI47O6OA7 (diallyl disulfide)
RN  - 60G7CF7CWZ (allyl sulfide)
RN  - 7I4L2D0E9G (alliin)
RN  - 81R3X99M15 (S-allylcysteine)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Allium/*chemistry
MH  - Allyl Compounds/*pharmacology
MH  - Animals
MH  - Cell Line
MH  - Chemokine CCL2/metabolism
MH  - Cysteine/analogs & derivatives/pharmacology
MH  - Disulfides/pharmacology
MH  - Garlic/*chemistry
MH  - Inflammation/chemically induced/*drug therapy/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Microglia/*drug effects/metabolism
MH  - NF-kappa B/metabolism
MH  - Neurodegenerative Diseases/drug therapy/metabolism
MH  - Nitric Oxide/metabolism
MH  - Plant Extracts/chemistry/pharmacology
MH  - Sulfides/pharmacology
MH  - Sulfur Compounds/*pharmacology
MH  - Tumor Necrosis Factor-alpha/metabolism
PMC - PMC6271092
COIS- The authors declare no conflict of interest.
EDAT- 2014/11/05 06:00
MHDA- 2015/10/16 06:00
PMCR- 2014/10/31
CRDT- 2014/11/04 06:00
PHST- 2014/09/19 00:00 [received]
PHST- 2014/10/17 00:00 [revised]
PHST- 2014/10/20 00:00 [accepted]
PHST- 2014/11/04 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
PHST- 2014/10/31 00:00 [pmc-release]
AID - molecules191117697 [pii]
AID - molecules-19-17697 [pii]
AID - 10.3390/molecules191117697 [doi]
PST - epublish
SO  - Molecules. 2014 Oct 31;19(11):17697-714. doi: 10.3390/molecules191117697.