PMID- 25366602
OWN - NLM
STAT- MEDLINE
DCOM- 20150316
LR  - 20151119
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 120
DP  - 2015
TI  - Effects of tenascin-C on early brain injury after subarachnoid hemorrhage in 
      rats.
PG  - 69-73
LID - 10.1007/978-3-319-04981-6_12 [doi]
AB  - BACKGROUND AND PURPOSE: We previously reported that tenascin-C (TNC), a 
      matricellular protein, was involved in the pathogenesis of cerebral vasospasm 
      after subarachnoid hemorrhage (SAH), but the role of TNC in early brain injury 
      (EBI) is unknown. This study assessed whether inhibition of TNC upregulation in 
      brain by imatinib mesylate (imatinib), an inhibitor of the tyrosine kinases of 
      platelet-derived growth factor receptors, prevents EBI after experimental SAH. 
      METHODS: Rats were assigned to sham, SAH plus vehicle, and SAH plus imatinib 
      groups (n = 4 per group). Imatinib (50 mg/kg body weight) was administered 
      intraperitoneally to rats undergoing SAH by endovascular perforation, and EBI was 
      evaluated using terminal deoxynucleotidyl transferase-mediated uridine 
      5-triphosphate-biotin nick end-labeling staining at 24 h after SAH. 
      Imatinib-treated SAH rats were also treated by a cisternal injection of 
      recombinant TNC. RESULTS: SAH upregulated TNC and caused EBI. Imatinib treatment 
      suppressed both TNC upregulation and EBI at 24 h. Recombinant TNC reinduced EBI 
      in imatinib-treated SAH rats. CONCLUSIONS: TNC may be involved in the 
      pathogenesis of EBI after SAH.
FAU - Shiba, Masato
AU  - Shiba M
AD  - Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 
      Edobashi, Tsu, Mie, 514-8507, Japan, mshiba@clin.medic.mie-u.ac.jp.
FAU - Fujimoto, Masashi
AU  - Fujimoto M
FAU - Kawakita, Fumio
AU  - Kawakita F
FAU - Imanaka-Yoshida, Kyoko
AU  - Imanaka-Yoshida K
FAU - Yoshida, Toshimichi
AU  - Yoshida T
FAU - Kanamaru, Kenji
AU  - Kanamaru K
FAU - Taki, Waro
AU  - Taki W
FAU - Suzuki, Hidenori
AU  - Suzuki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
RN  - 0 (Benzamides)
RN  - 0 (Piperazines)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Pyrimidines)
RN  - 0 (Tenascin)
RN  - 8A1O1M485B (Imatinib Mesylate)
SB  - IM
MH  - Animals
MH  - Benzamides/*pharmacology
MH  - Brain Injuries/*drug therapy/metabolism/pathology
MH  - Disease Models, Animal
MH  - Imatinib Mesylate
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Piperazines/*pharmacology
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Pyrimidines/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - Subarachnoid Hemorrhage/*drug therapy/metabolism/pathology
MH  - Tenascin/*antagonists & inhibitors/metabolism
MH  - Up-Regulation/drug effects
EDAT- 2014/11/05 06:00
MHDA- 2015/03/17 06:00
CRDT- 2014/11/05 06:00
PHST- 2014/11/05 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/03/17 06:00 [medline]
AID - 10.1007/978-3-319-04981-6_12 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2015;120:69-73. doi: 10.1007/978-3-319-04981-6_12.