PMID- 25366991
OWN - NLM
STAT- MEDLINE
DCOM- 20151030
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 4
DP  - 2014 Nov 4
TI  - High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic 
      plaque enabled by a 2-kHz barium nitrite raman laser.
PG  - 6889
LID - 10.1038/srep06889 [doi]
LID - 6889
AB  - Lipid deposition inside the arterial wall is a key indicator of plaque 
      vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a 
      promising device for quantifying the amount of lipid inside the arterial wall. 
      Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to 
      the lack of a suitable laser source for high-speed excitation of molecular 
      overtone vibrations. Here, we report an improvement in IVPA imaging speed by two 
      orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master 
      oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. 
      This advancement narrows the gap in translating the IVPA technology to the 
      clinical setting.
FAU - Wang, Pu
AU  - Wang P
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, 
      47906, USA.
FAU - Ma, Teng
AU  - Ma T
AD  - Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, 
      University of Southern California, Los Angeles, California 90089, USA.
FAU - Slipchenko, Mikhail N
AU  - Slipchenko MN
AD  - 1] Weldon School of Biomedical Engineering, Purdue University, West Lafayette, 
      47906, USA [2] Spectral Energy, LLC, Dayton, Ohio, 45431, USA.
FAU - Liang, Shanshan
AU  - Liang S
AD  - 1] Department of Biomedical Engineering, University of California, Irvine, 
      California 92697, USA [2] Beckman Laser Institute, University of California, 
      Irvine, California 92612, USA and Edwards Lifesciences Center for Advanced 
      Cardiovascular Technology, University of California, Irvine, California 92697, 
      USA.
FAU - Hui, Jie
AU  - Hui J
AD  - Physics Department, Purdue University, West Lafayette, 47906, USA.
FAU - Shung, K Kirk
AU  - Shung KK
AD  - Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, 
      University of Southern California, Los Angeles, California 90089, USA.
FAU - Roy, Sukesh
AU  - Roy S
AD  - Spectral Energy, LLC, Dayton, Ohio, 45431, USA.
FAU - Sturek, Michael
AU  - Sturek M
AD  - Department of Cellular &Integrative Physiology, Indiana University School of 
      Medicine, Indianapolis, Indiana, 46202, USA.
FAU - Zhou, Qifa
AU  - Zhou Q
AD  - Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, 
      University of Southern California, Los Angeles, California 90089, USA.
FAU - Chen, Zhongping
AU  - Chen Z
AD  - Department of Biomedical Engineering, University of California, Irvine, 
      California 92697, USA.
FAU - Cheng, Ji-Xin
AU  - Cheng JX
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, 
      47906, USA.
LA  - eng
GR  - R21 EB15901/EB/NIBIB NIH HHS/United States
GR  - P41 EB002182/EB/NIBIB NIH HHS/United States
GR  - P41 EB015890/EB/NIBIB NIH HHS/United States
GR  - R01 EB010090/EB/NIBIB NIH HHS/United States
GR  - R01 HL125084/HL/NHLBI NIH HHS/United States
GR  - R01EB-10090/EB/NIBIB NIH HHS/United States
GR  - P41-RR2182/RR/NCRR NIH HHS/United States
GR  - P41EB-015890/EB/NIBIB NIH HHS/United States
GR  - R21 EB015901/EB/NIBIB NIH HHS/United States
GR  - R01-HL-125084/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141104
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - Diagnostic Imaging/*instrumentation
MH  - Iliac Artery/pathology
MH  - Lasers
MH  - Lipids/*analysis
MH  - Phantoms, Imaging
MH  - Photoacoustic Techniques/*instrumentation
MH  - Plaque, Atherosclerotic/*pathology
MH  - Swine
MH  - Swine, Miniature
PMC - PMC4219167
COIS- Yes there is potential Competing Interest. JXC has a financial interest in 
      Vibonix Inc, which does not support this work. ZC has a financial interest in OCT 
      Medical Inc., which does not support this work.
EDAT- 2014/11/05 06:00
MHDA- 2015/10/31 06:00
PMCR- 2014/11/04
CRDT- 2014/11/05 06:00
PHST- 2014/07/09 00:00 [received]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2014/11/05 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/10/31 06:00 [medline]
PHST- 2014/11/04 00:00 [pmc-release]
AID - srep06889 [pii]
AID - 10.1038/srep06889 [doi]
PST - epublish
SO  - Sci Rep. 2014 Nov 4;4:6889. doi: 10.1038/srep06889.