PMID- 25367335
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20220330
IS  - 1000-467X (Print)
IS  - 1944-446X (Electronic)
IS  - 1944-446X (Linking)
VI  - 33
IP  - 11
DP  - 2014 Nov
TI  - The interplay of host genetic factors and Epstein-Barr virus in the development 
      of nasopharyngeal carcinoma.
PG  - 556-68
LID - 10.5732/cjc.014.10170 [doi]
AB  - The interplay between host cell genetics and Epstein-Barr virus (EBV) infection 
      contributes to the development of nasopharyngeal carcinoma (NPC). Understanding 
      the host genetic and epigenetic alterations and the influence of EBV on cell 
      signaling and host gene regulation will aid in understanding the molecular 
      pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and 
      therapy. In this review, we provide an update of the oncogenes and tumor 
      suppressor genes associated with NPC, as well as genes associated with NPC risk 
      including those involved in carcinogen detoxification and DNA repair. We also 
      describe the importance of host genetics that govern the human leukocyte antigen 
      (HLA) complex and immune responses, and we describe the impact of EBV infection 
      on host cell signaling changes and epigenetic regulation of gene expression. 
      High-power genomic sequencing approaches are needed to elucidate the genetic 
      basis for inherited susceptibility to NPC and to identify the genes and pathways 
      driving its molecular pathogenesis.
FAU - Lung, Maria Li
AU  - Lung ML
AD  - Department of Clinical Oncology and Center for Nasopharyngeal Carcinoma Research, 
      University of Hong Kong, Hong Kong, P. R. China. mlilung@hku.hk.
FAU - Cheung, Arthur Kwok Leung
AU  - Cheung AK
FAU - Ko, Josephine Mun Yee
AU  - Ko JM
FAU - Lung, Hong Lok
AU  - Lung HL
FAU - Cheng, Yue
AU  - Cheng Y
FAU - Dai, Wei
AU  - Dai W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Chin J Cancer
JT  - Chinese journal of cancer
JID - 101498232
SB  - IM
MH  - Carcinoma
MH  - *Epigenesis, Genetic
MH  - *Epstein-Barr Virus Infections
MH  - Genes, Tumor Suppressor
MH  - *Genetic Predisposition to Disease
MH  - Herpesvirus 4, Human/genetics
MH  - Humans
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*etiology
MH  - Oncogenes
MH  - Signal Transduction
PMC - PMC4244319
EDAT- 2014/11/05 06:00
MHDA- 2015/09/02 06:00
PMCR- 2014/11/01
CRDT- 2014/11/05 06:00
PHST- 2014/11/05 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - cjc.014.10170 [pii]
AID - cjc-33-11-556 [pii]
AID - 10.5732/cjc.014.10170 [doi]
PST - ppublish
SO  - Chin J Cancer. 2014 Nov;33(11):556-68. doi: 10.5732/cjc.014.10170.