PMID- 25367550
OWN - NLM
STAT- MEDLINE
DCOM- 20151208
LR  - 20161125
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 85
IP  - 5
DP  - 2015 Apr
TI  - Gender-related clinical and echocardiographic outcomes at 30-day and 12-month 
      follow up after MitraClip implantation in the GRASP registry.
PG  - 889-97
LID - 10.1002/ccd.25715 [doi]
AB  - OBJECTIVES: To assess the influence of patients' gender on the outcomes of 
      percutaneous edge-to-edge mitral valve repair (PMVR) using the MitraClip system. 
      BACKGROUND: Although gender-related differences have been extensively documented 
      in patients who undergo surgery for moderate-to-severe (3+) and severe (4+) 
      mitral regurgitation (MR), studies assessing whether these differences exist 
      after PMVR are lacking. METHODS: Clinical and echocardiographic data through 
      12-month follow up from 171 consecutive patients whom underwent MitraClip 
      implantation and were dichotomized by the gender (106 males and 65 females) were 
      obtained. The primary safety endpoint was the incidence of major adverse events 
      at 30 days and the primary efficacy endpoint was freedom from death, surgery for 
      mitral valve dysfunction, or grade>/=3+ MR at 12-month follow up. RESULTS: The 
      primary safety endpoint was observed in four males (3.8%) and four females (6.2%) 
      (P=0.358). Remarkable reduction in MR postprocedure was revealed in both groups, 
      and these results were mostly sustained. Furthermore, left ventricle reverse 
      remodeling and New York Heart Association (NYHA) functional class improvement 
      were revealed in both groups, but females tended to demonstrate worse results 
      over time (P=0.083). The primary efficacy endpoint obtained by Kaplan-Meier 
      estimates was observed in 76.3 and 70.2%, respectively (log rank P=0.231). 
      CONCLUSIONS: MitraClip implantation in patients with 3+ and 4+ MR is safe and 
      efficacious until mid-term follow up, regardless of patients' gender. Despite 
      improvement in NYHA functional class in both groups, female gender demonstrated a 
      trend toward poorer results. Further validation of our findings is warranted.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Attizzani, Guilherme F
AU  - Attizzani GF
AD  - Division of Cardiology, Ferrarotto Hospital, University of Catania, Catania, 
      Italy; Interventional Cardiology Department, Pitangueiras Hospital, Jundiai, 
      Brazil; Harrington Heart and Vascular Institute, University Hospitals, Case 
      Medical Center, Cleveland, Ohio.
FAU - Ohno, Yohei
AU  - Ohno Y
FAU - Capodanno, Davide
AU  - Capodanno D
FAU - Cannata, Stefano
AU  - Cannata S
FAU - Dipasqua, Fabio
AU  - Dipasqua F
FAU - Imme, Sebastiano
AU  - Imme S
FAU - Mangiafico, Sarah
AU  - Mangiafico S
FAU - Barbanti, Marco
AU  - Barbanti M
FAU - Ministeri, Margherita
AU  - Ministeri M
FAU - Cageggi, Anna
AU  - Cageggi A
FAU - Pistritto, Anna Maria
AU  - Pistritto AM
FAU - Giaquinta, Sandra
AU  - Giaquinta S
FAU - Farruggio, Silvia
AU  - Farruggio S
FAU - Chiaranda, Marta
AU  - Chiaranda M
FAU - Ronsivalle, Giuseppe
AU  - Ronsivalle G
FAU - Scandura, Salvatore
AU  - Scandura S
FAU - Tamburino, Corrado
AU  - Tamburino C
FAU - Capranzano, Piera
AU  - Capranzano P
FAU - Grasso, Carmelo
AU  - Grasso C
LA  - eng
PT  - Journal Article
DEP - 20141110
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
CIN - Catheter Cardiovasc Interv. 2015 Apr;85(5):898. PMID: 25789735
MH  - Aged
MH  - *Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - Incidence
MH  - Italy/epidemiology
MH  - Male
MH  - Mitral Valve/*surgery
MH  - Mitral Valve Insufficiency/diagnostic imaging/*surgery
MH  - Postoperative Complications/*epidemiology
MH  - Prosthesis Design
MH  - *Registries
MH  - Sex Factors
MH  - Time Factors
OTO - NOTNLM
OT  - MitraClip
OT  - gender
OT  - mitral insufficiency
OT  - mitral regurgitation
OT  - percutaneous mitral valve repair
EDAT- 2014/11/05 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/11/05 06:00
PHST- 2014/07/21 00:00 [received]
PHST- 2014/10/25 00:00 [accepted]
PHST- 2014/11/05 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1002/ccd.25715 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2015 Apr;85(5):889-97. doi: 10.1002/ccd.25715. Epub 
      2014 Nov 10.