PMID- 25367742
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20141121
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 6
DP  - 2014 Dec
TI  - Maternal HLA-C2 and 14 bp insertion in HLA-G is associated with recurrent 
      implantation failure after in vitro fertilization treatment.
PG  - 536-44
LID - 10.1111/tan.12452 [doi]
AB  - The major rate-limiting step in in vitro fertilization (IVF) success appears to 
      be the implantation of the semi-allogeneic embryo into the maternal endometrium. 
      To determine possible risk factors of recurrent failure of embryos to implant, we 
      investigated immunogenetic determinants as level of human leukocyte antigen (HLA) 
      histocompatibility, frequency of killer-cell immunoglobulin-like receptors (KIR) 
      and HLA-C alleles and HLA-G polymorphism. We DNA typed women with recurrent 
      implantation failure (RIF) and their partners for classical HLA Class I, HLA 
      Class II, HLA-G and KIR alleles and compared these results with couples with 
      successful embryo implantation after their first IVF and normal fertile couples. 
      No association was found between RIF and the degree of histocompatibility between 
      partners or sharing of a specific antigen. Also, no significant difference in KIR 
      haplotype or combination of HLA-C group and KIR was observed. We did find a 
      higher frequency of HLA-C2 and a higher frequency of 14 base pair (bp) insertion 
      in HLA-G in women with RIF. Therefore we conclude that the degree of 
      histocompatibility between partners is not a determining factor for the 
      occurrence of RIF. However, presence of the HLA-C2 allotype and the HLA-G allele 
      with a 14 bp insertion is a significant risk factor.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lashley, L E E L O
AU  - Lashley LE
AD  - Department of Gynaecology and Obstetrics, Leiden University Medical Centre, 
      Leiden, the Netherlands.
FAU - van der Westerlaken, L A J
AU  - van der Westerlaken LA
FAU - Haasnoot, G W
AU  - Haasnoot GW
FAU - Drabbels, J J M
AU  - Drabbels JJ
FAU - Spruyt-Gerritse, M J
AU  - Spruyt-Gerritse MJ
FAU - Scherjon, S A
AU  - Scherjon SA
FAU - Claas, F H J
AU  - Claas FH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20141104
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Embryo Implantation/*genetics/immunology
MH  - Female
MH  - *Fertilization in Vitro
MH  - Gene Frequency
MH  - HLA-C Antigens/*genetics/immunology
MH  - HLA-G Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - *INDEL Mutation
MH  - Infertility, Female/*genetics/immunology
MH  - Risk Factors
OTO - NOTNLM
OT  - HLA-C
OT  - HLA-G
OT  - histocompatibility
OT  - in vitro fertilization
OT  - killer-cell immunoglobulin-like receptors
OT  - recurrent implantation failure
EDAT- 2014/11/05 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/11/05 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/08/21 00:00 [revised]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2014/11/05 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1111/tan.12452 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Dec;84(6):536-44. doi: 10.1111/tan.12452. Epub 2014 Nov 4.