PMID- 25368105
OWN - NLM
STAT- MEDLINE
DCOM- 20150618
LR  - 20181202
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 38
IP  - 1
DP  - 2015 Jan
TI  - CD247, a novel T cell-derived diagnostic and prognostic biomarker for detecting 
      disease progression and severity in patients with type 2 diabetes.
PG  - 113-8
LID - 10.2337/dc14-1544 [doi]
AB  - OBJECTIVE: We have previously shown that chronic inflammation results in 
      immunosuppression associated with CD247 downregulation in T lymphocytes. Type 2 
      diabetes mellitus (T2DM) is known to be associated with chronic inflammation. We 
      therefore sought to examine CD247 expression levels in patients with T2DM and to 
      assess whether it can serve as a diagnostic and prognostic biomarker for disease 
      complications and outcomes. RESEARCH DESIGN AND METHODS: Peripheral blood samples 
      from 75 T2DM patients and 40 healthy control subjects were collected and analyzed 
      for the expression level of CD247 in T lymphocytes. Subjects with T2DM underwent 
      a medical interview with physical examination and were followed for an additional 
      average of 19.2 +/- 0.9 months to determine the occurrence of major adverse disease 
      end points. The relationship between the level of CD247 expression and disease 
      status at the time of blood draw and the ability of the marker to identify future 
      complications was evaluated. RESULTS: We observed a significant reduction in 
      CD247 expression levels in T lymphocytes of T2DM patients when compared with 
      healthy volunteers. CD247 downregulation was associated with disease severity, 
      complications, and the occurrence of future cardiovascular events, suggesting its 
      potential use not only as a diagnostic but also as a prognostic biomarker. 
      CONCLUSIONS: Our results suggest the use of CD247 as a biomarker in diabetic 
      patients for evaluating the state of chronic inflammation that contributes to 
      morbidity and mortality in this disease and for the prediction of future 
      cardiovascular events.
CI  - (c) 2015 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Eldor, Roy
AU  - Eldor R
AD  - Diabetes Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, 
      Jerusalem, Israel.
FAU - Klieger, Yair
AU  - Klieger Y
AD  - The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical 
      Research Institute, Faculty of Medicine, The Hebrew University of Jerusalem, 
      Jerusalem, Israel Improdia Ltd., Herzliya, Israel.
FAU - Sade-Feldman, Moshe
AU  - Sade-Feldman M
AD  - The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical 
      Research Institute, Faculty of Medicine, The Hebrew University of Jerusalem, 
      Jerusalem, Israel.
FAU - Vaknin, Ilan
AU  - Vaknin I
AD  - The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical 
      Research Institute, Faculty of Medicine, The Hebrew University of Jerusalem, 
      Jerusalem, Israel.
FAU - Varfolomeev, Inna
AU  - Varfolomeev I
AD  - The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical 
      Research Institute, Faculty of Medicine, The Hebrew University of Jerusalem, 
      Jerusalem, Israel.
FAU - Fuchs, Camil
AU  - Fuchs C
AD  - Department of Statistics and Operations Research, Tel-Aviv University, Ramat 
      Aviv, Tel Aviv, Israel.
FAU - Baniyash, Michal
AU  - Baniyash M
AD  - The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical 
      Research Institute, Faculty of Medicine, The Hebrew University of Jerusalem, 
      Jerusalem, Israel michalb@ekmd.huji.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141103
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Biomarkers)
RN  - 0 (CD3 Complex)
RN  - 0 (CD3 antigen, zeta chain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*metabolism
MH  - CD3 Complex/genetics/*metabolism
MH  - Cardiovascular Diseases/complications/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/genetics
MH  - *Disease Progression
MH  - Down-Regulation
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Inflammation/complications/*diagnosis/genetics
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes/*metabolism
EDAT- 2014/11/05 06:00
MHDA- 2015/06/19 06:00
CRDT- 2014/11/05 06:00
PHST- 2014/11/05 06:00 [entrez]
PHST- 2014/11/05 06:00 [pubmed]
PHST- 2015/06/19 06:00 [medline]
AID - dc14-1544 [pii]
AID - 10.2337/dc14-1544 [doi]
PST - ppublish
SO  - Diabetes Care. 2015 Jan;38(1):113-8. doi: 10.2337/dc14-1544. Epub 2014 Nov 3.