PMID- 25370917
OWN - NLM
STAT- MEDLINE
DCOM- 20151209
LR  - 20221207
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 36
IP  - 4
DP  - 2015 Apr
TI  - MCP-1 and CCR2 gene polymorphisms in Parkinson's disease in a Han Chinese cohort.
PG  - 571-6
LID - 10.1007/s10072-014-1990-3 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC chemokine 
      receptor-2 (CCR2) play important roles in neuroinflammation and they have been 
      shown to be involved in Parkinson's disease (PD) pathogenesis. In addition, 
      several studies have suggested a role for the MCP-1 and CCR2 genotypes in 
      cognitive impairment and depression, which are common non-motor symptoms in PD 
      patients. In this study, a cohort of 521 PD patients and 556 cases of healthy 
      controls were recruited to investigate the association between the MCP-1 2518A/G 
      (rs1064211) and CCR2 V64I (rs1799864) gene polymorphisms and PD risk in the 
      Chinese population. We also analyze the influence of these genotypes on the 
      cognitive function and depression in PD patients by comparing Mini-Mental State 
      Examination (MMSE), Montreal Cognitive Assessment (MoCA), Wechsler Adult 
      Intelligence Scale-Chinese Revision (WAIS-RC), Wechsler Memory Scale-Chinese 
      Revision (WMS-RC) and Hamilton Depression Rating Scale (HAMD) ratings in 217 PD 
      patients. Our results showed no significant differences in the genotype frequency 
      between the PD group and the control group (P > 0.05). In addition, we also 
      failed to find an influence of the MCP-1 and CCR2 genotypes on MMSE scores, MoCA 
      scores, WAIS-RC scores, WMS-RC scores and HAMD scores in PD patients (P > 0.05). 
      The MCP-1 and CCR2 gene polymorphisms may not be genetic risk factors for PD in 
      the Han Chinese population, and they do not appear to influence cognitive 
      function and depression in PD patients.
FAU - Gao, Liang
AU  - Gao L
AD  - Department of Neurology, Guangdong Neuroscience Institute, Guangdong General 
      Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Rd II, Guangzhou, 
      510080, Guangdong Province, People's Republic of China, gaoliang0123@sina.com.
FAU - Tang, Hongmei
AU  - Tang H
FAU - Nie, Kun
AU  - Nie K
FAU - Wang, Limin
AU  - Wang L
FAU - Zhao, Jiehao
AU  - Zhao J
FAU - Gan, Rong
AU  - Gan R
FAU - Huang, Jing
AU  - Huang J
FAU - Feng, Shujun
AU  - Feng S
FAU - Zhu, Ruiming
AU  - Zhu R
FAU - Duan, Zhenpeng
AU  - Duan Z
FAU - Zhang, Youwen
AU  - Zhang Y
FAU - Zhao, Xin
AU  - Zhao X
FAU - Zhang, Yuhu
AU  - Zhang Y
FAU - Wang, Lijuan
AU  - Wang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141105
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Asian People/ethnology/genetics
MH  - Chemokine CCL2/*genetics
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Parkinson Disease/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Receptors, CCR2/*genetics
EDAT- 2014/11/06 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/11/06 06:00
PHST- 2014/07/15 00:00 [received]
PHST- 2014/10/24 00:00 [accepted]
PHST- 2014/11/06 06:00 [entrez]
PHST- 2014/11/06 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s10072-014-1990-3 [doi]
PST - ppublish
SO  - Neurol Sci. 2015 Apr;36(4):571-6. doi: 10.1007/s10072-014-1990-3. Epub 2014 Nov 
      5.