PMID- 25371533 OWN - NLM STAT- MEDLINE DCOM- 20150630 LR - 20141105 IS - 1899-1505 (Electronic) IS - 0867-5910 (Linking) VI - 65 IP - 5 DP - 2014 Oct TI - The influence of moderate-intensity physical effort on peripheral blood in adults with Down syndrome - a pilot study. PG - 733-8 AB - The aim of this study was to evaluate the influence of a six-week aerobic training on peripheral blood in adults with Down syndrome. Fifteen men with Down syndrome (average age 22.4 years +/- 0.91) with moderate or severe intellectual disability took part in the study. Patients underwent a training program three times a week for six weeks. Venous blood samples of 10 ml were collected from every examined patient, 24 hours before and after the exercise. The blood samples were submitted to hematological examination (hematocrit, fibrinogen, plasma viscosity, red blood cell (RBC) number, RBC indicators: mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH)), reduced glutathione (GSH) level and number of macrocytes, polikilocytrometric examination of RBC and rheological blood examination (elongation index (EI), aggregation index (AI), syllectogram amplitude (AMP), aggregation half time (t1/2)) was made by LORCA. Amoderate six-week physical training performed on a cycloergometer resulted in a statistically significant decrease in the MCV value, hematocrit and plasma viscosity. The six-week cycloergometer training caused a statistically significant increase in the GSH level and erythrocyte pliability at a shear stress of 0.58 Pa. FAU - Aleksander-Szymanowicz, P AU - Aleksander-Szymanowicz P AD - Department of Occupational Therapy, Academy of Physical Education, Cracow, Poland. paulina.aleksander@gmail.com. FAU - Marchewka, A AU - Marchewka A FAU - Dabrowski, Z AU - Dabrowski Z FAU - Teleglow, A AU - Teleglow A FAU - Bac, A AU - Bac A FAU - Glodzik, J AU - Glodzik J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Poland TA - J Physiol Pharmacol JT - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JID - 9114501 RN - GAN16C9B8O (Glutathione) SB - IM MH - Adult MH - Blood Viscosity MH - Down Syndrome/*blood/physiopathology MH - Erythrocyte Count MH - Erythrocyte Indices MH - Erythrocytes/cytology/physiology MH - Glutathione/blood MH - Hematocrit MH - Humans MH - Male MH - *Physical Exertion MH - Pilot Projects MH - Young Adult EDAT- 2014/11/06 06:00 MHDA- 2015/07/01 06:00 CRDT- 2014/11/06 06:00 PHST- 2013/04/30 00:00 [received] PHST- 2014/08/19 00:00 [accepted] PHST- 2014/11/06 06:00 [entrez] PHST- 2014/11/06 06:00 [pubmed] PHST- 2015/07/01 06:00 [medline] PST - ppublish SO - J Physiol Pharmacol. 2014 Oct;65(5):733-8.