PMID- 25371910
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Immunomodulation by Trypanosoma cruzi: toward understanding the association of 
      dendritic cells with infecting TcI and TcII populations.
PG  - 962047
LID - 10.1155/2014/962047 [doi]
LID - 962047
AB  - Dendritic cells (DCs) are major immune components, and depending on how these 
      cells are modulated, the protective host immune response changes drastically. 
      Trypanosoma cruzi is a parasite with high genetic variability and modulates DCs 
      by interfering with their capacity for antigen recognition, migration, and 
      maturation. Despite recent efforts, the association between DCs and T. cruzi I 
      (TcI) and TcII populations is unknown. Herein, it was demonstrated that AQ1.7 and 
      MUTUM TcI strains present low rates of invasion of bone marrow-derived DCs, 
      whereas the 1849 and 2369 TcII strains present higher rates. Whereas the four 
      strains similarly induced the expression of PD-L1, the production and expression 
      of IL-10 and TLR-2, respectively, in DCs were differentially increased. The 
      production of TNF-alpha, IL-12, IL-6, and CCL2 and the expression of CD40, CD80, 
      MHC-II, CCR5, and CCR7 changed depending on the strain. The 2369 strain yielded 
      the most remarkable results because greater invasion correlated with an increase 
      in the levels of anti-inflammatory molecules IL-10 and PD-L1 but not with a 
      change in the levels of TNF-alpha, MHC-II, or CD40 molecules. These results suggest 
      that T. cruzi strains belonging to different populations have evolved specific 
      evasion strategies that subvert DCs and consequently the host response.
FAU - da Costa, Thiago Alvares
AU  - da Costa TA
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Immunology, Federal University of Triangulo Mineiro, Avenida Getulio Guarita S/N, 
      38015-050 Uberaba, MG, Brazil.
FAU - Silva, Marcos Vinicius
AU  - Silva MV
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Immunology, Federal University of Triangulo Mineiro, Avenida Getulio Guarita S/N, 
      38015-050 Uberaba, MG, Brazil.
FAU - Mendes, Maria Tays
AU  - Mendes MT
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Immunology, Federal University of Triangulo Mineiro, Avenida Getulio Guarita S/N, 
      38015-050 Uberaba, MG, Brazil.
FAU - Carvalho-Costa, Tamires Marielem
AU  - Carvalho-Costa TM
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Immunology, Federal University of Triangulo Mineiro, Avenida Getulio Guarita S/N, 
      38015-050 Uberaba, MG, Brazil.
FAU - Batista, Lara Rocha
AU  - Batista LR
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Parasitology, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
FAU - Lages-Silva, Eliane
AU  - Lages-Silva E
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Parasitology, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
FAU - Rodrigues, Virmondes
AU  - Rodrigues V
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Immunology, Federal University of Triangulo Mineiro, Avenida Getulio Guarita S/N, 
      38015-050 Uberaba, MG, Brazil.
FAU - Oliveira, Carlo Jose
AU  - Oliveira CJ
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Immunology, Federal University of Triangulo Mineiro, Avenida Getulio Guarita S/N, 
      38015-050 Uberaba, MG, Brazil.
FAU - Ramirez, Luis Eduardo
AU  - Ramirez LE
AD  - Postgraduate Course of Tropical Medicine and Infectology, Laboratory of 
      Parasitology, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20141013
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-H1 Antigen)
RN  - 0 (CCR5 protein, mouse)
RN  - 0 (CD40 Antigens)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Ccr7 protein, mouse)
RN  - 0 (Cd274 protein, mouse)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Tlr2 protein, mouse)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Animals
MH  - B7-1 Antigen/immunology/metabolism
MH  - B7-H1 Antigen/immunology/metabolism
MH  - CD40 Antigens/immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism/parasitology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Histocompatibility Antigens Class II/immunology/metabolism
MH  - Host-Parasite Interactions/*immunology
MH  - Immune System Phenomena/*immunology
MH  - Interleukin-10/immunology/metabolism
MH  - Interleukin-12/immunology/metabolism
MH  - Interleukin-6/immunology/metabolism
MH  - Mice, Inbred C57BL
MH  - Receptors, CCR2/immunology/metabolism
MH  - Receptors, CCR5/immunology/metabolism
MH  - Receptors, CCR7/immunology/metabolism
MH  - Species Specificity
MH  - Toll-Like Receptor 2/immunology/metabolism
MH  - Trypanosoma cruzi/classification/*immunology/physiology
MH  - Tumor Necrosis Factor-alpha/immunology/metabolism
PMC - PMC4211313
EDAT- 2014/11/06 06:00
MHDA- 2015/06/24 06:00
PMCR- 2014/10/13
CRDT- 2014/11/06 06:00
PHST- 2014/06/06 00:00 [received]
PHST- 2014/08/12 00:00 [revised]
PHST- 2014/09/09 00:00 [accepted]
PHST- 2014/11/06 06:00 [entrez]
PHST- 2014/11/06 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
PHST- 2014/10/13 00:00 [pmc-release]
AID - 10.1155/2014/962047 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:962047. doi: 10.1155/2014/962047. Epub 2014 Oct 13.