PMID- 25372579
OWN - NLM
STAT- MEDLINE
DCOM- 20150617
LR  - 20221207
IS  - 1677-9487 (Electronic)
IS  - 0004-2730 (Linking)
VI  - 58
IP  - 7
DP  - 2014 Oct
TI  - Serum levels of retinol binding protein 4 in women with different levels of 
      adiposity and glucose tolerance.
PG  - 709-14
LID - S0004-27302014000700709 [pii]
AB  - OBJECTIVE: Retinol-binding protein 4 (RBP4) is an adipokine responsible for 
      vitamin A (retinol) transportation. Studies associated RBP4 increased levels with 
      severity of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The 
      study aimed to quantify RBP4 serum standards in women with a wide range of body 
      mass index (BMI) and glucose tolerance level. SUBJECTS AND METHODS: 
      Cross-sectional study was performed with 139 women divided into three groups: 
      Group 1 (lean-control, n = 45) and Group 2 (obese, n = 53) with normal glucose 
      tolerance and group 3 (obese with T2DM, n = 41), called G1, G2 and G3. Were 
      assessed clinical, biochemical, anthropometric and body composition parameters. 
      RESULTS: According to data analysis, we obtained in G1 higher RBP4 levels (104.8 
      +/- 76.8 ng/mL) when compared to G2 (87.9 +/- 38 ng/mL) and G3 (72.2 +/- 15.6 ng/mL) 
      levels. Also, were found: in G1 positive correlations of RBP4 with BMI (r = 
      0.253), glycated hemoglobin (r = 0.378) and fasting insulin (r = 0.336); in G2 
      with glycated hemoglobin (r = 0.489); in G3 with glycated hemoglobin (r = 0.330), 
      fasting glucose (r = 0.463), HOMA-IR (r = 0.481). CONCLUSIONS: Although RBP4 have 
      shown lower levels in diabetic and obese, a strong correlation with HOMA-IR index 
      highlights that, in our study, there is growing IR when there is an increasing in 
      RBP4 levels.
FAU - Comucci, Eleonora Beltrame
AU  - Comucci EB
AD  - Laboratory of Investigation on Metabolism and Diabetes, Department of Internal 
      Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, 
      SP, Brazil.
FAU - Vasques, Ana Carolina Junqueira
AU  - Vasques AC
AD  - Laboratory of Investigation on Metabolism and Diabetes, Department of Internal 
      Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, 
      SP, Brazil.
FAU - Geloneze, Bruno
AU  - Geloneze B
AD  - Laboratory of Investigation on Metabolism and Diabetes, Department of Internal 
      Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, 
      SP, Brazil.
FAU - Calixto, Antonio Ramos
AU  - Calixto AR
AD  - Laboratory of Investigation on Metabolism and Diabetes, Department of Internal 
      Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, 
      SP, Brazil.
FAU - Pareja, Jose Carlos
AU  - Pareja JC
AD  - Laboratory of Investigation on Metabolism and Diabetes, Department of Internal 
      Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, 
      SP, Brazil.
FAU - Tambascia, Marcos Antonio
AU  - Tambascia MA
AD  - Laboratory of Investigation on Metabolism and Diabetes, Department of Internal 
      Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, 
      SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Arq Bras Endocrinol Metabol
JT  - Arquivos brasileiros de endocrinologia e metabologia
JID - 0403437
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Retinol-Binding Proteins)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - *Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/physiology
MH  - Middle Aged
MH  - Obesity/*metabolism
MH  - Retinol-Binding Proteins/*metabolism
EDAT- 2014/11/06 06:00
MHDA- 2015/06/18 06:00
CRDT- 2014/11/06 06:00
PHST- 2012/10/17 00:00 [received]
PHST- 2014/07/30 00:00 [accepted]
PHST- 2014/11/06 06:00 [entrez]
PHST- 2014/11/06 06:00 [pubmed]
PHST- 2015/06/18 06:00 [medline]
AID - S0004-27302014000700709 [pii]
AID - 10.1590/0004-2730000002431 [doi]
PST - ppublish
SO  - Arq Bras Endocrinol Metabol. 2014 Oct;58(7):709-14. doi: 
      10.1590/0004-2730000002431.