PMID- 25373446
OWN - NLM
STAT- MEDLINE
DCOM- 20151110
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 40
IP  - 1
DP  - 2015 Jan
TI  - Hyaluronan tetrasaccharide exerts neuroprotective effect and promotes functional 
      recovery after acute spinal cord injury in rats.
PG  - 98-108
LID - 10.1007/s11064-014-1470-4 [doi]
AB  - The objective of this study was to explore the therapeutic efficiency of 
      hyaluronan tetrasaccharide (HA4) treatment after spinal cord injury (SCI) in rats 
      and to investigate the underlying mechanism. Locomotor functional and 
      electrophysiological evaluations revealed that the behavioral function of rats in 
      the HA4-treated group was significantly improved compared with the 
      vehicle-treated group. The expression of brain-derived neurotrophic factor 
      (BDNF), vascular endothelial growth factor (VEGF), cluster determinant (CD44) and 
      Toll-like receptor-4 (TLR-4) was obviously upregulated in the HA4-treated group 
      than that in the sham and vehicle-treated group. Furthermore, HA4 could induce 
      BDNF and VEGF expression in the astrocytes in vitro. In addition, the high 
      expression of BDNF and VEGF could be inhibited by blocking CD44 and TLR-4. These 
      findings indicate that HA4 could be useful as a promising therapeutic agent for 
      SCI and might exert the effect by interaction with the CD44 and TLR-4.
FAU - Wang, Jun
AU  - Wang J
AD  - Traumatology Department,Beijing Jishuitan Hospital, No. 31 East Street of Xin Jie 
      Kou Beijing, Beijing, 100035, People's Republic of China.
FAU - Wang, Xiaofang
AU  - Wang X
FAU - Wei, Jie
AU  - Wei J
FAU - Wang, Manyi
AU  - Wang M
LA  - eng
PT  - Journal Article
DEP - 20141106
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Oligosaccharides)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects/metabolism/ultrastructure
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Hyaluronan Receptors/metabolism
MH  - Hyaluronic Acid/*pharmacology
MH  - Locomotion/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Oligosaccharides/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function/*drug effects
MH  - Spinal Cord Injuries/*drug therapy/metabolism/physiopathology
MH  - Toll-Like Receptor 4/metabolism
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2014/11/07 06:00
MHDA- 2015/11/11 06:00
CRDT- 2014/11/07 06:00
PHST- 2014/06/25 00:00 [received]
PHST- 2014/10/30 00:00 [accepted]
PHST- 2014/09/11 00:00 [revised]
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2015/11/11 06:00 [medline]
AID - 10.1007/s11064-014-1470-4 [doi]
PST - ppublish
SO  - Neurochem Res. 2015 Jan;40(1):98-108. doi: 10.1007/s11064-014-1470-4. Epub 2014 
      Nov 6.