PMID- 25373529
OWN - NLM
STAT- MEDLINE
DCOM- 20160323
LR  - 20150615
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 31
IP  - 3
DP  - 2015 Mar
TI  - The impact of body mass on inflammatory markers and insulin resistance in 
      polycystic ovary syndrome.
PG  - 225-8
LID - 10.3109/09513590.2014.976546 [doi]
AB  - OBJECTIVE: To evaluate inflammatory markers and insulin resistance (IR) in women 
      with and without polycystic ovary syndrome (PCOS), with different body mass index 
      (BMI). METHODS: Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and 
      C-reactive protein (CRP) were assessed in serum samples from 40 women in 
      reproductive age. Patients were divided into four groups: I (non-eutrophic with 
      PCOS, n = 12), II (non-eutrophic without PCOS, n = 10), III (eutrophic with PCOS, 
      n = 8) and IV (eutrophic without PCOS, n = 10) being non-eutrophic, the 
      overweight and obese women with BMI > 25 kg/m2 and eutrophic women with 
      BMI < 24.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for 
      evaluation of IR. RESULTS: PCOS patients showed increased levels of CRP 
      (p < 0.01) and HOMA-IR (p < 0.01). When divided by BMI, both non-eutrophicad 
      eutrophic PCOS showed increased CRP levels (p < 0.01) and HOMA-IR (p < 0.01). 
      There were no differences in TNF-alpha and IL-6 levels between groups. CONCLUSION: In 
      the PCOS group, the levels of CRP and IR were elevated, compared to their 
      counterparts, regardless of body mass.
FAU - Souza Dos Santos, Ana Celly
AU  - Souza Dos Santos AC
AD  - Graduate Program in Pharmaceutical Sciences - CCS , Natal, RN , Brazil .
FAU - Soares, Nayara Pereira
AU  - Soares NP
FAU - Costa, Eduardo Caldas
AU  - Costa EC
FAU - de Sa, Joceline Cassia Ferrezini
AU  - de Sa JC
FAU - Azevedo, George Dantas
AU  - Azevedo GD
FAU - Lemos, Telma Maria Araujo Moura
AU  - Lemos TM
LA  - eng
PT  - Journal Article
DEP - 20141106
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (IL6 protein, human)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - *Body Mass Index
MH  - C-Reactive Protein/*metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/blood/physiopathology
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Interleukin-6/*blood
MH  - Polycystic Ovary Syndrome/*blood/physiopathology
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Cytokines
OT  - inflammation
OT  - insulin resistance
OT  - nutritional status
OT  - obesity
OT  - ovary
OT  - polycystic ovary syndrome
EDAT- 2014/11/07 06:00
MHDA- 2016/03/24 06:00
CRDT- 2014/11/07 06:00
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2016/03/24 06:00 [medline]
AID - 10.3109/09513590.2014.976546 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2015 Mar;31(3):225-8. doi: 10.3109/09513590.2014.976546. Epub 
      2014 Nov 6.