PMID- 25373727
OWN - NLM
STAT- MEDLINE
DCOM- 20150807
LR  - 20221207
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 16
IP  - 1
DP  - 2015 Jan-Feb
TI  - Associations of HLA class I alleles in Japanese patients with Crohn's disease.
PG  - 54-6
LID - 10.1038/gene.2014.61 [doi]
AB  - Previous studies have suggested that the human leukocyte antigen (HLA) is 
      involved in the etiology of Crohn's disease (CD); however, few reports are 
      available on the association between HLA class I antigens and CD in Japan. In 
      this study, we performed association analysis of HLA class I antigens in CD using 
      208 Japanese patients and 384 healthy controls. We identified novel positive 
      associations between CD and HLA-A*02:01 (odds ratio (OR)=1.64, P=0.016) and 
      HLA-A*02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive 
      associations between CD and HLA-Cw*14:02 (OR=2.18, P=0.0021) and HLA-B*51:01 
      (OR=1.70, P=0.033). We also identified novel negative associations between CD and 
      HLA-A*24:02 (OR=0.60, P=0.0047) and HLA-B*07:02 (OR=0.38, P=0.0041). Although the 
      associations were not significant after full Bonferroni correction, we suggested 
      that HLA class I genes have dual functions, susceptibility and resistance in 
      controlling the development of CD.
FAU - Oryoji, D
AU  - Oryoji D
AD  - Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
FAU - Hisamatsu, T
AU  - Hisamatsu T
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
FAU - Tsuchiya, K
AU  - Tsuchiya K
AD  - Department of Advanced Therapeutics for Gastrointestinal Diseases, Graduate 
      School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
FAU - Umeno, J
AU  - Umeno J
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Ueda, S
AU  - Ueda S
AD  - Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
FAU - Yamamoto, K
AU  - Yamamoto K
AD  - Department of Medical Chemistry, Kurume University School of Medicine, Fukuoka, 
      Japan.
FAU - Matsumoto, T
AU  - Matsumoto T
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Watanabe, M
AU  - Watanabe M
AD  - Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and 
      Dental University, Bunkyo-ku, Tokyo, Japan.
FAU - Hibi, T
AU  - Hibi T
AD  - 1] Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan [2] Center for 
      Advanced IBD Research and Treatment, Kitasato University Kitasato Institute 
      Hospital, Minato-ku, Tokyo, Japan.
FAU - Sasazuki, T
AU  - Sasazuki T
AD  - Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141106
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Crohn Disease/*genetics
MH  - Genes, MHC Class I
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Japan
EDAT- 2014/11/07 06:00
MHDA- 2015/08/08 06:00
CRDT- 2014/11/07 06:00
PHST- 2014/05/31 00:00 [received]
PHST- 2014/08/29 00:00 [revised]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2015/08/08 06:00 [medline]
AID - gene201461 [pii]
AID - 10.1038/gene.2014.61 [doi]
PST - ppublish
SO  - Genes Immun. 2015 Jan-Feb;16(1):54-6. doi: 10.1038/gene.2014.61. Epub 2014 Nov 6.