PMID- 25374002
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20150306
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 79
IP  - 3
DP  - 2015
TI  - Cholesterol-lowering effect of rice bran protein containing bile acid-binding 
      proteins.
PG  - 456-61
LID - 10.1080/09168451.2014.978260 [doi]
AB  - Dietary plant protein is well known to reduce serum cholesterol levels. Rice bran 
      is a by-product of rice milling and is a good source of protein. The present 
      study examined whether feeding rats a high-cholesterol diet containing 10% rice 
      bran protein (RBP) for 10 d affected cholesterol metabolism. Rats fed dietary RBP 
      had lower serum total cholesterol levels and increased excretion of fecal 
      steroids, such as cholesterol and bile acids, than those fed dietary casein. In 
      vitro assays showed that RBP strongly bound to taurocholate, and inhibited the 
      micellar solubility of cholesterol, compared with casein. Moreover, the bile 
      acid-binding proteins of the RBP were eluted by a chromatographic column 
      conjugated with cholic acid, and one of them was identified as hypothetical 
      protein OsJ_13801 (NCBI accession No. EAZ29742) using MALDI-TOF mass spectrometry 
      analysis. These results suggest that the hypocholesterolemic action of the RBP 
      may be caused by the bile acid-binding proteins.
FAU - Wang, Jilite
AU  - Wang J
AD  - a Faculty of Applied Biological Sciences, Department of Applied Life Science , 
      Gifu University , Gifu , Japan.
FAU - Shimada, Masaya
AU  - Shimada M
FAU - Kato, Yukina
AU  - Kato Y
FAU - Kusada, Mio
AU  - Kusada M
FAU - Nagaoka, Satoshi
AU  - Nagaoka S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141106
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Dietary Proteins)
RN  - 0 (Micelles)
RN  - 5E090O0G3Z (Taurocholic Acid)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Anticholesteremic Agents/chemistry/*metabolism/*pharmacology
MH  - Cholesterol/chemistry/metabolism
MH  - Diet/adverse effects
MH  - Dietary Proteins/chemistry/*metabolism/*pharmacology
MH  - Male
MH  - Micelles
MH  - Oryza/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Solubility
MH  - Taurocholic Acid/*metabolism
OTO - NOTNLM
OT  - bile acid
OT  - cholesterol
OT  - micelle
OT  - rice bran protein
EDAT- 2014/11/07 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/11/07 06:00
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1080/09168451.2014.978260 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2015;79(3):456-61. doi: 10.1080/09168451.2014.978260. 
      Epub 2014 Nov 6.