PMID- 25374127
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20181202
IS  - 1860-1499 (Electronic)
IS  - 1860-1499 (Linking)
VI  - 49
IP  - 3
DP  - 2016 Sep
TI  - Cystic apocrine ductal carcinoma in situ with increased EGFR expression, trisomy 
      7, and associated focal invasion.
PG  - 170-6
LID - 10.1007/s00795-014-0091-y [doi]
AB  - A 71-year-old woman was admitted to our hospital with a lump in her right breast. 
      Mammography revealed an internal high-density mass in the lower right breast, 
      which was larger than it was 2 years ago. Considering the findings from 
      ultrasonography, computed tomography, and cytology, an intracystic carcinoma 
      could not be ruled out. The patient underwent excisional biopsy, which revealed 
      an apocrine ductal carcinoma in situ (ADCIS) with focal invasive apocrine 
      carcinoma (IAC). The diagnosis was based on morphology and immunohistochemistry 
      (IHC), which was negative for the estrogen and progesterone receptors, and 
      positive for the androgen receptor. Expression of the human epidermal growth 
      factor receptor 2 and the epidermal growth factor receptor (EGFR) received an 
      immunohistochemical score of 2+. Trisomy of chromosome 7, including multiple CEP 
      7 and EGFR signals, was observed in ADCIS by fluorescence in situ hybridization 
      (FISH). IAC exhibited similar results for IHC and FISH. This is the first 
      reported case showing trisomy 7 resulting in EGFR copy number gain and increased 
      EGFR expression in ADCIS.
FAU - Tajima, Shogo
AU  - Tajima S
AD  - Department of Pathology, Shizuoka Saiseikai General Hospital, 1-1-1 Oshika, 
      Suruga-ku, Shizuoka, 422-8021, Japan. stajima-tky@umin.ac.jp.
FAU - Waki, Michihiko
AU  - Waki M
AD  - Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 
      Shizuoka, Japan.
FAU - Nasu, Hatsuko
AU  - Nasu H
AD  - Department of Radiology, Hamamatsu University School of Medicine, Shizuoka, 
      Japan.
FAU - Ide, Yoshimi
AU  - Ide Y
AD  - Department of Surgery I, Hamamatsu University School of Medicine, Shizuoka, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20141106
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Aged
MH  - Apocrine Glands/*pathology
MH  - Breast Neoplasms/diagnostic imaging/*genetics/*pathology
MH  - Carcinoma, Ductal, Breast/diagnostic imaging/*genetics/*pathology
MH  - ErbB Receptors/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Mammography
MH  - Neoplasm Invasiveness
MH  - *Trisomy
OTO - NOTNLM
OT  - Apocrine ductal carcinoma in situ
OT  - Chromosome 7
OT  - Epidermal growth factor receptor
OT  - Invasive apocrine carcinoma
OT  - Trisomy
EDAT- 2014/11/07 06:00
MHDA- 2017/03/28 06:00
CRDT- 2014/11/07 06:00
PHST- 2014/09/22 00:00 [received]
PHST- 2014/10/23 00:00 [accepted]
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
AID - 10.1007/s00795-014-0091-y [pii]
AID - 10.1007/s00795-014-0091-y [doi]
PST - ppublish
SO  - Med Mol Morphol. 2016 Sep;49(3):170-6. doi: 10.1007/s00795-014-0091-y. Epub 2014 
      Nov 6.