PMID- 25374355
OWN - NLM
STAT- MEDLINE
DCOM- 20150121
LR  - 20220419
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 84
IP  - 2
DP  - 2014 Oct 22
TI  - The neurology of mTOR.
PG  - 275-91
LID - S0896-6273(14)00892-7 [pii]
LID - 10.1016/j.neuron.2014.09.034 [doi]
AB  - The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial 
      cellular signaling hub that, like the nervous system itself, integrates internal 
      and external cues to elicit critical outputs including growth control, protein 
      synthesis, gene expression, and metabolic balance. The importance of mTOR 
      signaling to brain function is underscored by the myriad disorders in which mTOR 
      pathway dysfunction is implicated, such as autism, epilepsy, and 
      neurodegenerative disorders. Pharmacological manipulation of mTOR signaling holds 
      therapeutic promise and has entered clinical trials for several disorders. Here, 
      we review the functions of mTOR signaling in the normal and pathological brain, 
      highlighting ongoing efforts to translate our understanding of cellular 
      physiology into direct medical benefit for neurological disorders.
FAU - Lipton, Jonathan O
AU  - Lipton JO
AD  - F.M. Kirby Center for Neurobiology, Translational Neuroscience Center, Department 
      of Neurology, Boston Children's Hospital, Boston, MA 02115, USA; Division of 
      Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
FAU - Sahin, Mustafa
AU  - Sahin M
AD  - F.M. Kirby Center for Neurobiology, Translational Neuroscience Center, Department 
      of Neurology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic 
      address: mustafa.sahin@childrens.harvard.edu.
LA  - eng
GR  - P20 NS080199/NS/NINDS NIH HHS/United States
GR  - K08 HD071026/HD/NICHD NIH HHS/United States
GR  - U54 NS092090/NS/NINDS NIH HHS/United States
GR  - P30 HD018655/HD/NICHD NIH HHS/United States
GR  - U01 NS082320/NS/NINDS NIH HHS/United States
GR  - K08HD071026-03/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20141022
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Brain/metabolism/physiopathology
MH  - Central Nervous System Diseases/*metabolism/therapy
MH  - Humans
MH  - Neuronal Plasticity/*physiology
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC4223653
MID - NIHMS634395
EDAT- 2014/11/07 06:00
MHDA- 2015/01/22 06:00
PMCR- 2015/10/22
CRDT- 2014/11/07 06:00
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2015/01/22 06:00 [medline]
PHST- 2015/10/22 00:00 [pmc-release]
AID - S0896-6273(14)00892-7 [pii]
AID - 10.1016/j.neuron.2014.09.034 [doi]
PST - ppublish
SO  - Neuron. 2014 Oct 22;84(2):275-91. doi: 10.1016/j.neuron.2014.09.034. Epub 2014 
      Oct 22.