PMID- 25374428
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 42
IP  - 2
DP  - 2015 Feb
TI  - Interleukin-18 gene promoter polymorphisms and celiac disease in Italian 
      patients.
PG  - 525-33
LID - 10.1007/s11033-014-3796-z [doi]
AB  - Celiac disease (CD) is the most common food-sensitive enteropathy in genetically 
      susceptible individuals. The major genetic risk factors known are specific human 
      leukocyte antigen (HLA)-DQ haplotypes, but other genetic factors are supposed to 
      be involved. Interleukin-18 (IL-18) is a pro-inflammatory cytokine that has an 
      important role in the immune defense and it has the potential to influence 
      inflammatory disorders. IL-18 is able to promote Th1 cell development and it is 
      expressed in the mucosa of the small intestine in celiac patients. Given the 
      IL-18 biological role, and since a few studies have previously suggested its 
      involvement in CD, in order to investigate the role of IL18 gene in the 
      susceptibility to CD we have performed a case-control study, analyzing two IL18 
      gene promoter polymorphisms, previously reported to impair the transcriptional 
      activity of the gene, (-137G > C and -607C > A, rs187238 and rs1946518 
      respectively). A total of 556 CD Italian patients and 582 controls, further 
      stratified for HLA class II (DQ) CD risk haplotypes were enrolled. The -607A > C 
      A allele and A/A genotype, as well as the combination of this allele with the 
      -137G allele in the AG haplotype, were associated with an increased risk towards 
      CD development, in particular in HLA-DQ2.2 patients. Although the association was 
      very moderate, our results indicate the possible involvement of IL18 gene in the 
      susceptibility to CD, and for this reason we do think it should deserve further 
      investigation.
FAU - Zupin, Luisa
AU  - Zupin L
AD  - Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", via dell'Istria 
      65/1, 34137, Trieste, Italy.
FAU - Catamo, Eulalia
AU  - Catamo E
FAU - Polesello, Vania
AU  - Polesello V
FAU - Crovella, Sergio
AU  - Crovella S
FAU - Segat, Ludovica
AU  - Segat L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141106
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (HLA Antigens)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Celiac Disease/*epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Italy/epidemiology
MH  - Male
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - White People
EDAT- 2014/11/07 06:00
MHDA- 2016/02/26 06:00
CRDT- 2014/11/07 06:00
PHST- 2013/05/16 00:00 [received]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2014/11/07 06:00 [entrez]
PHST- 2014/11/07 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.1007/s11033-014-3796-z [doi]
PST - ppublish
SO  - Mol Biol Rep. 2015 Feb;42(2):525-33. doi: 10.1007/s11033-014-3796-z. Epub 2014 
      Nov 6.