PMID- 25376093
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20181113
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 7
DP  - 2014 Nov 6
TI  - Association between single-nucleotide polymorphisms and early spontaneous 
      hepatitis B virus e antigen seroconversion in children.
PG  - 789
LID - 10.1186/1756-0500-7-789 [doi]
LID - 789
AB  - BACKGROUND: The disease progression following hepatitis B virus (HBV) infection 
      is associated with single-nucleotide polymorphisms (SNPs). However, the role of 
      SNPs in chronic HBV infection in children remains unclear. Here, we investigate 
      the association between SNPs and early spontaneous hepatitis B e antigen (HBeAg) 
      seroconversion in children with chronic hepatitis B infection. METHODS: This was 
      a retrospective cohort study. We genotyped seven SNPs in the following genes, 
      interleukin (IL)-10 (rs1800871 and rs1800872), human leukocyte antigen (HLA)-DPA1 
      (rs3077), HLA-DPB1 (rs9277535), HLA-DQB2 (rs7453920), HLA-DQB1 (rs2856718), and 
      IL28B (rs8099917), in patients with chronic HBV infection using PCR and 
      sequencing. These variants were analyzed for an association with early HBeAg 
      seroconversion in children. RESULTS: Of 225 Japanese patients with chronic 
      hepatitis B virus infection (male/female: 105/120, median age at initial visit: 6 
      years; range 0-44 years), 52 achieved spontaneous HBeAg seroconversion at the age 
      of 10 years or younger (G1: early seroconversion group), and 57 did not achieve 
      spontaneous HBeAg seroconversion under the age of 20 years (G2: late or no 
      seroconversion group). Of the seven SNPs, only the HLA-DPA1 SNP displayed a low 
      p-value (P = 0.070), but not significant, to have early HBeAg seroconversion in 
      the dominant model and in the allele model (P = 0.073) using the chi-square test. 
      The association study found a low p-value, but not significant, to have early 
      HBeAg seroconversion in the dominant model for HLA-DPA1 (genotype TC + TT vs. CC, 
      P = 0.070, odds ratio: 2.016, 95% confidence interval: 0.940-4.323) using a 
      logistic regression model. CONCLUSION: Although the HLA-DPA1 SNP did not show a 
      statistically significant association with early HBeAg seroconversion in this 
      study, the HLA-DPA1 SNP might increase the likelihood of achieving early 
      spontaneous HBeAg seroconversion in children.
FAU - Komatsu, Haruki
AU  - Komatsu H
AD  - Department of Pediatrics, Toho University, Sakura Medical Center, 564-1 
      Shimoshizu Sakura, Chiba 285-8741, Japan. haruki-komatsu@chive.ocn.ne.jp.
FAU - Murakami, Jun
AU  - Murakami J
FAU - Inui, Ayano
AU  - Inui A
FAU - Tsunoda, Tomoyuki
AU  - Tsunoda T
FAU - Sogo, Tsuyoshi
AU  - Sogo T
FAU - Fujisawa, Tomoo
AU  - Fujisawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141106
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Hepatitis B e Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Genetic Association Studies
MH  - Hepatitis B e Antigens/*blood
MH  - Hepatitis B, Chronic/*blood/*genetics/virology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Young Adult
PMC - PMC4230755
EDAT- 2014/11/08 06:00
MHDA- 2015/07/07 06:00
PMCR- 2014/11/06
CRDT- 2014/11/08 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/10/24 00:00 [accepted]
PHST- 2014/11/08 06:00 [entrez]
PHST- 2014/11/08 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
PHST- 2014/11/06 00:00 [pmc-release]
AID - 1756-0500-7-789 [pii]
AID - 3299 [pii]
AID - 10.1186/1756-0500-7-789 [doi]
PST - epublish
SO  - BMC Res Notes. 2014 Nov 6;7:789. doi: 10.1186/1756-0500-7-789.